Prenatal lead (Pb) exposure is associated with differential placental DNA methylation and hydroxymethylation in a human population

Prenatal lead (Pb) exposure is associated with adverse developmental outcomes and to epigenetic alterations such as DNA methylation and hydroxymethylation in animal models and in newborn blood. Given the importance of the placenta in foetal development, we sought to examine how prenatal Pb exposure...

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Bibliographic Details
Published in:Epigenetics 2022-12, Vol.17 (13), p.2404-2420
Main Authors: Tung, Pei Wen, Kennedy, Elizabeth M., Burt, Amber, Hermetz, Karen, Karagas, Margaret, Marsit, Carmen J.
Format: Article
Language:English
Subjects:
DNA Methylation
Epigenesis, Genetic
epigenetics
Epigenomics
EWAS
Female
Humans
hydroxymethylation
Infant
Infant, Newborn
lead
Lead - metabolism
Lead - toxicity
Maternal Exposure - adverse effects
placenta
Placenta - metabolism
Pregnancy
Research Paper
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Summary:Prenatal lead (Pb) exposure is associated with adverse developmental outcomes and to epigenetic alterations such as DNA methylation and hydroxymethylation in animal models and in newborn blood. Given the importance of the placenta in foetal development, we sought to examine how prenatal Pb exposure was associated with differential placental DNA methylation and hydroxymethylation and to identify affected biological pathways linked to developmental outcomes. Maternal (n = 167) and infant (n = 172) toenail and placenta (n = 115) samples for prenatal Pb exposure were obtained from participants in a US birth cohort, and methylation and hydroxymethylation data were quantified using the Illumina Infinium MethylationEPIC BeadChip. An epigenome-wide association study was applied to identify differential methylation and hydroxymethylation associated with Pb exposure. Biological functions of the Pb-associated genes were determined by overrepresentation analysis through ConsensusPathDB. Prenatal Pb quantified from maternal toenail, infant toenail, and placenta was associated with 480, 27, and 2 differentially methylated sites (q 
ISSN:1559-2294
1559-2308
DOI:10.1080/15592294.2022.2126087