Tumor Growth Ameliorates Cardiac Dysfunction

Heart failure and cancer are the deadliest diseases worldwide. Murine models for cardiac remodeling and heart failure demonstrate that cardiac dysfunction promotes cancer progression and metastasis spread. Yet, no information is available on whether and how tumor progression affects cardiac remodeli...

Full description

Saved in:
Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2023-07, Vol.12 (14), p.1853
Main Authors: Awwad, Lama, Shofti, Rona, Haas, Tali, Aronheim, Ami
Format: Article
Language:English
Subjects:
Animal models
Animals
Aorta
Cancer
cardiac fibrosis
cardiac hypertrophy
Complications and side effects
Congestive heart failure
Fibrosis
Flow cytometry
Heart
Heart attacks
Heart diseases
Heart failure
Heart Failure - metabolism
Hypertrophy
immune system
Immunofluorescence
Laboratory animals
macrophage polarization
Macrophages
Metastases
Metastasis
Mice
Muscle contraction
Neoplasms
Risk factors
Surgery
tumor
Tumor cell lines
Tumors
Veins & arteries
Ventricular Remodeling
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Heart failure and cancer are the deadliest diseases worldwide. Murine models for cardiac remodeling and heart failure demonstrate that cardiac dysfunction promotes cancer progression and metastasis spread. Yet, no information is available on whether and how tumor progression affects cardiac remodeling. Here, we examined cardiac remodeling following transverse aortic constriction (TAC) in the presence or absence of proliferating cancer cells. We show that tumor-bearing mice, of two different cancer cell lines, display reduced cardiac hypertrophy, lower fibrosis and improved cardiac contractile function following pressure overload induced by TAC surgery. Integrative analysis of qRT-PCR, flow cytometry and immunofluorescence identified tumor-dependent M1-to-M2 polarization in the cardiac macrophage population as a mediator of the beneficial tumor effect on the heart. Importantly, tumor-bearing mice lacking functional macrophages fail to improve cardiac function and display sustained fibrosis.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells12141853