Venous thromboembolism and major bleeding in severe and critical COVID-19 hospitalized patients

• Published in: Monaldi archives for chest disease 2023-07
• Main Authors: Abate, Veronica, Vergatti, Anita, Casoria, Aniello, Zarrella, Aquilino Flavio, Muscariello, Riccardo, Nuzzo, Vincenzo, Vargas, Maria, Servillo, Giuseppe, Conca, Paolo, D'Elia, Lanfranco, Iannuzzo, Gabriella, Venetucci, Pietro, De Filippo, Gianpaolo, Rendina, Domenico, Tufano, Antonella
• Format: Article
• Language: English
• Subjects: bleeding; Covid-19; venous thromboembolism
• ISSN: 1122-0643; 2532-5264
• DOI: 10.4081/monaldi.2023.2617

Venous thromboembolism (VTE) and major bleeding (MB) are life-threatening complications described in COVID-19 hospitalized patients and they can be considered as two sides of the same coin. This retrospective study aims to evaluate the risk factors for VTE and MB in COVID-19 patients admitted to two Italian hospitals. The medical records of all COVID-19 patients (males 139; 62.3%, mean age 67.2±13.6 years, body weight 88.2±20.6 kg) hospitalized from March 11th to July 31st, 2020 to the Federico II University Hospital and to Sea Hospital, Naples, Italy, were analyzed. The COVID-19 patients were classified into four groups: COVID-19 patients developing VTE and/or MB, COVID-19 patients developing only VTE, COVID-19 patients developing only MB, and COVID-19 patients not developing neither VTE nor MB. During the hospitalization, 53 COVID-19 patients (24.7%; males 40; 75.5%, mean age 67.2±13.6 years, weight 88.2±20.6 kg) developed VTE, 33 COVID-19 patients (15.3 %; males 17; 51.5, mean age 67.3±14.9 years, weight 74.1±14.3 kg) developed MB, and 129 COVID-19 patients not developed neither TVP nor MB. No parameters to identify severe COVID-19 complicated by VTE and/or MB were found. However, some clinical and biochemical parameters can be evaluated to predict the risk of MB in order to modify the treatment and take prompt action to reduce mortality.