Case report: Successful treatment of acute generalized pustular psoriasis with multiple comorbidities with oral tacrolimus

Acute generalized pustular psoriasis (GPP) is a serious illness. Despite various treatment methods, there is still lack of effective treatment plans for refractory cases with multiple comorbidities. This case report presents a 67-year-old woman with acute GPP, stage 4 chronic kidney disease (CKD), t...

Full description

Saved in:
Bibliographic Details
Published in:Frontiers in immunology 2024-03, Vol.15, p.1354578
Main Authors: Zhao, Mingdan, Huang, Fujun, Tang, Lei, Zhou, Xun, Zhang, Miao, Liao, Mengxue, Liu, Lirong, Huang, Mengya
Format: Article
Language:English
Subjects:
Acute Disease
acute generalized pustular psoriasis
Aged
case report
Chronic Disease
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - drug therapy
Female
Humans
Immunology
Interleukins
oral
Psoriasis - complications
Psoriasis - diagnosis
Psoriasis - drug therapy
Renal Insufficiency, Chronic - complications
tacrolimus
Tacrolimus - therapeutic use
treatment
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Acute generalized pustular psoriasis (GPP) is a serious illness. Despite various treatment methods, there is still lack of effective treatment plans for refractory cases with multiple comorbidities. This case report presents a 67-year-old woman with acute GPP, stage 4 chronic kidney disease (CKD), type 2 diabetes, and cardiovascular disease, in whom skin symptom disappearance and kidney function improvement were observed after the use of oral tacrolimus as the sole therapy. This is the first report on the application of tacrolimus in the treatment of acute GPP, especially refractory acute GPP. The successful treatment indicates that there are shared immune pathways between acute GPP and CKD, and the pathways can be interdicted by tacrolimus. Further studies are needed to optimize the therapy to maximize efficacy and minimize toxicity.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2024.1354578