Relationship of genetic causes and inhibin B in non obstructive azoospermia spermatogenic failure

Chromosomal disorders in non obstructive azoospermia (NOA) may have an important influence on spermatogenesis, which may be reflected by the serum inhibin B levels. Till now, few studies have concerned the relationship of genetic causes and inhibin B in NOA. In this retrospective study, 322 men with...

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Bibliographic Details
Published in:BMC medical genetics 2017-09, Vol.18 (1), p.98-98, Article 98
Main Authors: Chu, Qing-Jun, Hua, Rui, Luo, Chen, Chen, Qing-Jie, Wu, Biao, Quan, Song, Zhu, Yong-Tong
Format: Article
Language:English
Subjects:
Adult
Aspermia
Azoospermia - blood
Azoospermia - genetics
Biopsy
Chromosome Deletion
Chromosomes
Chromosomes, Human, Y
Deoxyribonucleic acid
DNA
Follicle Stimulating Hormone
Genetic aspects
Genetic counseling
Genetic testing
Health aspects
Humans
Identification and classification
Infertility
Inhibin
Inhibin B
Inhibins - blood
Inversion
Karyotype
Karyotypes
Karyotyping
Male
Males
Mosaics
Non obstruction azoospermia
Retrospective Studies
Sex Chromosome Aberrations
Sperm
Spermatogenesis
Spermatogenesis - genetics
Statistical analysis
Y chromosome microdeletion
Y chromosomes
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Summary:Chromosomal disorders in non obstructive azoospermia (NOA) may have an important influence on spermatogenesis, which may be reflected by the serum inhibin B levels. Till now, few studies have concerned the relationship of genetic causes and inhibin B in NOA. In this retrospective study, 322 men with NOA in Center for Reproductive Medicine, Nanfang Hospital, Southern Medical University were collected. The level of follicle stimulating hormone (FSH), inhibin B, Y chromosome microdeletion test (YCMD) and karyotype were measured. Abnormal karyotypes were present in 38.5% of NOA, and YCMD were present in 18.0%, there was a high correlation between karyotypes and YCMD (χ  = 11.892, P 
ISSN:1471-2350
1471-2350
DOI:10.1186/s12881-017-0456-x