The angiotensin-converting enzyme I/D polymorphism does not impact training-induced adaptations in exercise capacity in patients with stable coronary artery disease

Systematic exercise training effectively improves exercise capacity in patients with coronary artery disease (CAD), but the magnitude of improvements is highly heterogeneous. We investigated whether this heterogeneity in exercise capacity gains is influenced by the insertion/deletion (I/D) polymorph...

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Published in:Scientific reports 2023-10, Vol.13 (1), p.18300-18300, Article 18300
Main Authors: Sjúrðarson, Tórur, Kristiansen, Jacobina, Nordsborg, Nikolai B., Gregersen, Noomi O., Lydersen, Leivur N., Grove, Erik L., Kristensen, Steen D., Hvas, Anne-Mette, Mohr, Magni
Format: Article
Language:English
Subjects:
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Angiotensin
Cardiovascular disease
Coronary artery disease
Coronary vessels
Enzymes
Fitness training programs
Gene deletion
Gene polymorphism
Genotype & phenotype
Heart diseases
Heterogeneity
Heterozygotes
Homozygotes
Humanities and Social Sciences
Maximum oxygen consumption
multidisciplinary
Oxygen
Oxygen uptake
Peptidyl-dipeptidase A
Physical training
Polymorphism
Science
Science (multidisciplinary)
Vein & artery diseases
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Summary:Systematic exercise training effectively improves exercise capacity in patients with coronary artery disease (CAD), but the magnitude of improvements is highly heterogeneous. We investigated whether this heterogeneity in exercise capacity gains is influenced by the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene. Patients with CAD (n = 169) were randomly assigned to 12 weeks of exercise training or standard care, and 142 patients completed the study. The ACE polymorphism was determined for 128 patients (82% males, 67 ± 9 years). Peak oxygen uptake was measured before and after the 12-week intervention. The ACE I/D polymorphism frequency was n = 48 for D/D homozygotes, n = 61 for I/D heterozygotes and n = 19 for I/I homozygotes. Baseline peak oxygen uptake was 23.3 ± 5.0 ml/kg/min in D/D homozygotes, 22.1 ± 5.3 ml/kg/min in I/D heterozygotes and 23.1 ± 6.0 ml/kg/min in I/I homozygotes, with no statistical differences between genotype groups ( P  = 0.50). The ACE I/D polymorphism frequency in the exercise group was n = 26 for D/D, n = 21 for I/D and n = 12 for I/I. After exercise training, peak oxygen uptake was increased ( P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-45542-0