The Roles of Lipoprotein in Psoriasis

The association between psoriasis and cardiovascular disease risk has been supported by recent epidemiological data. Patients with psoriasis have an increased adjusted relative risk for myocardial infarction. As such, the cardiovascular risk conferred by severe psoriasis may be comparable to what is...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-01, Vol.21 (3), p.859
Main Authors: Shih, Chun-Ming, Chen, Chang-Cyuan, Chu, Chen-Kuo, Wang, Kuo-Hsien, Huang, Chun-Yao, Lee, Ai-Wei
Format: Article
Language:English
Subjects:
Adhesion
Antigens
Atherogenesis
Atherosclerosis
Blood vessels
Cardiovascular diseases
Cell adhesion molecules
Chemokines
Cholesterol
Cytokines
Dendritic cells
Dermis
Diabetes mellitus
Disease
Endothelial cells
Endothelium
Epidemiology
Hyperlipidemia
Hyperplasia
Immune system
Immunology
Inflammation
Intercellular adhesion molecule 1
Kinases
Leukocytes (mononuclear)
lipid
Lipids
Lipoproteins
Low density lipoprotein
Lymphocytes
Macrophages
Myocardial infarction
Osmosis
Psoriasis
Review
Risk analysis
Risk factors
Skin
Skin diseases
Transcription factors
Tumor necrosis factor-TNF
Vascular cell adhesion molecule 1
Vascular endothelial growth factor
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Summary:The association between psoriasis and cardiovascular disease risk has been supported by recent epidemiological data. Patients with psoriasis have an increased adjusted relative risk for myocardial infarction. As such, the cardiovascular risk conferred by severe psoriasis may be comparable to what is seen with other well-established risk factors, such as diabetes mellitus. Previous studies demonstrated that low-density lipoprotein (LDL) plays critical roles during atherogenesis. It may be caused by the accumulation of macrophages and lipoprotein in the vessel wall. Oxidized LDL (ox-LDL) stimulates the expression of adhesion molecules, such as ICAM-1 and VCAM-1, on endothelial cells and increases the attachment of mononuclear cells and the endothelium. Even though previous evidence demonstrated that psoriasis patients have tortuous and dilated blood vessels in the dermis, which results in the leakage of ox-LDL, the leaked ox-LDL may increase the expression of adhesion molecules and cytokines, and disturb the static balance of osmosis. Therefore, exploration of the relationship between hyperlipidemia and psoriasis may be another novel treatment option for psoriasis and may represent the most promising strategy.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21030859