Different Trajectories for Diabetes Mellitus Onset and Recovery According to the Centralized Aerobic-Anaerobic Energy Balance Compensation Theory

We recently reported that the restoration of cervical vertebral arterial blood flow access (measured as systolic peak (PS)) to the rhomboid fossa leads to the recovery of the HbA1c level in the case of patients with a pre-Diabetes Mellitus (pre-DM) condition. The theory of centralized aerobic-anaero...

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Published in:Biomedicines 2023-07, Vol.11 (8), p.2147
Main Authors: Vetcher, Alexandre A, Zhukov, Kirill V, Gasparyan, Bagrat A, Borovikov, Pavel I, Karamian, Arfenia S, Rejepov, Dovlet T, Kuznetsova, Maria N, Shishonin, Alexander Y
Format: Article
Language:English
Subjects:
Adaptation
Analysis
Animal models
arterial hypertension
Blood flow
blood pressure
Cerebellum
Diabetes mellitus
Energy
Energy balance
Equilibrium
HbA1c
Heart rate
Hypertension
Hypoxia
Mathematical models
Metabolism
Prediabetic state
rhomboid fossa
systolic peak
Veins & arteries
Vertebrae
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Summary:We recently reported that the restoration of cervical vertebral arterial blood flow access (measured as systolic peak (PS)) to the rhomboid fossa leads to the recovery of the HbA1c level in the case of patients with a pre-Diabetes Mellitus (pre-DM) condition. The theory of centralized aerobic-anaerobic energy balance compensation (TCAAEBC) provides a successful theoretical explanation for this observation. It considers the human body as a dissipative structure. Reported connections between arterial hypertension (AHT) and the level of HbA1c are linked through OABFRH. According to the TCAAEBC, this delivers incorrect information about blood oxygen availability to the cerebellum. The restoration of PS normalizes AHT in 5-6 weeks and HbA1c in 12-13 weeks. In the current study, we demonstrate the model which fits the obtained experimental data. According to the model, pathways of onset and recovery from pre-DM are different. The consequence of these differences is discussed. The great significance of the TCAAEBC for medical practice forces the creation of an appropriate mathematical model, but the required adjustment of the model needs experimental data which can only be obtained from an animal model(s). The essential part of this study is devoted to the analysis of the advantages and disadvantages of widely available common mammalian models for TCAAEBC cases.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11082147