Synthesis of Platinum Complexes from N-Benzyl-1,3-Propanediamine Derivatives, Potential Antineoplastic Agents

This work describes the synthesis of seven new platinum complexes having Nbenzyl 1,3-propanediamine derivatives as ligands. They were prepared by the reaction of K2[PtCl4] with the appropriate ligand in water. These complexes are analogs of cisplatin, and are potential antineoplastic agents.

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2002-04, Vol.7 (4), p.405-411
Main Authors: De Almeida, Mauro Vieira, Fontes, Ana Paula Soares, Berg, Richard Nilton, César, Eloi Teixeira, De Castro Antunes Felício, Emanoel, De Souza Filho, José Dias
Format: Article
Language:English
Subjects:
3-propanediamine
anticancer agents
Cancer
Ethanol
Ligands
N-benzyl 1
Platinum(II) complexes
Tumors
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Summary:This work describes the synthesis of seven new platinum complexes having Nbenzyl 1,3-propanediamine derivatives as ligands. They were prepared by the reaction of K2[PtCl4] with the appropriate ligand in water. These complexes are analogs of cisplatin, and are potential antineoplastic agents.
ISSN:1420-3049
1420-3049
DOI:10.3390/70400405