Evaluation of serum magnesium, lipid profile and various biochemical parameters as risk factors of cardiovascular diseases in patients with rheumatoid arthritis

• Published in: Journal of clinical and diagnostic research 2015-04, Vol.9 (4), p.BC01-BC05
• Main Authors: Chavan, Vilas U, Ramavataram, Dvss, Patel, Payal A, Rupani, Mihir P
• Format: Article
• Language: English
• Subjects: Biochemistry Section; cardiovascular risk factors; dyslipidemia; inflammatory; uric acid
• ISSN: 2249-782X; 0973-709X
• DOI: 10.7860/JCDR/2015/12206.5740

Rheumatoid arthritis (RA) is chronic inflammatory disease, associated with increased risk of cardiovascular diseases (CVD) than the general population. Chronic inflammatory conditions are likely to alter magnesium level and various biochemical parameters. To study the probable changes in serum magnesium, lipid profile and various biochemical parameters and to assess risk factors of CVD in newly diagnosed RA patients compared to controls. We studied 50 newly diagnosed RA adult patients and 50 healthy individuals as controls. Serum magnesium, calcium, lipid profile, uric acid and other biochemical parameters were measured in study subjects. Results were expressed as Mean ± SD and compared between RA subjects and controls by Independent sample t-test and Pearson correlation. We found decreased serum magnesium and calcium in RA subjects compared to the controls (p < 0.001). RA subjects had atherogenic lipid profile characterized by elevated total cholesterol (p = 0.054), LDL cholesterol (p = 0.008) and decreased HDL cholesterol (p