Functional Capacity and Inflammatory Mediators in Elderly Residents of Counties with Different Human Development Index

• Published in: Journal of aging research 2020, Vol.2020 (2020), p.1-7
• Main Authors: Pereira, Leani S. M., Parentoni, Adriana N., Pereira, Daniele Sirineu, Ribeiro-Samora, Giane A., Xavier, Daniele R., Lustosa, Lygia P., Thomasini, Ronaldo L.
• Format: Article
• Language: English
• Subjects: Access to education; Analysis; Cytokines; Education; Ethylenediaminetetraacetic acid; Human Development Index; Interleukins; Kruskal-Wallis test; Life expectancy; Older people; Quality of life; Social aspects; Sociodemographics; Statistical analysis; Studies; Tumor necrosis factor; Tumor necrosis factor-TNF; Variance analysis; Womens health
• ISSN: 2090-2204; 2090-2212; 2090-2212
• DOI: 10.1155/2020/9250929

A number of studies have indicated that certain factors, including socioeconomic status and education, are associated with the functional health status of the elderly. Another relevant factor in aging is chronic subliminal inflammation, with increased levels of circulating inflammatory cytokines such as interleukin-6 (IL-6), tumor necrosis factor α (TNF-α), and soluble tumor necrosis factor receptor 1 (sTNFR-1), commonly seen in the elderly. High levels of these inflammatory mediators could impair the functional capacity. In this respect, the aim of this cross-sectional study was to compare plasma levels of inflammatory mediators and functional capacity of older women living in three Brazilian counties with different Human Development Index. We evaluated 154 women aged ≥65 years, regardless of race and/or social status. IL-6 and sTNFR-1 plasma levels were measured by ELISA and the functional capacity by the Short Physical Performance Battery (SPPB) test. Comparison among groups was performed using one-way ANOVA with Bonferroni post hoc correction, Kruskal–Wallis, and Mann–Whitney U tests. Women that lived in one of the counties with high HDI had lower functional capacity (p