Multifunctional Triamcinolone Acetonide Microneedle Patches for Atopic Dermatitis Treatment

Atopic dermatitis (AD), a chronic and inflammatory skin disease, has brought huge physiological and psychological burdens to patients, which causes wide concerns in society. Herein, a multifunctional microneedle (MN) patch is proposed integrated with a desirable moisturizer and intelligent drug deli...

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Bibliographic Details
Published in:Small structures 2024-12, Vol.5 (12), p.n/a
Main Authors: Song, Liwan, Fan, Lu, Zhang, Qingfei, Huang, Shanshan, Kong, Bin, Xiao, Jian, Xu, Ye
Format: Article
Language:English
Subjects:
atopic dermatitis
Composite materials
Controllability
Dermatitis
drug delivery
Health services
Hyaluronic acid
hydrogels
microneedle patches
Near infrared radiation
Needles
Polyvinylpyrrolidone
Quantum dots
responsiveness
Tips
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Summary:Atopic dermatitis (AD), a chronic and inflammatory skin disease, has brought huge physiological and psychological burdens to patients, which causes wide concerns in society. Herein, a multifunctional microneedle (MN) patch is proposed integrated with a desirable moisturizer and intelligent drug delivery capacity for AD treatment. Such MN patch consists of hyaluronic acid (HA) backing and near‐infrared (NIR) responsive tips containing black phosphorous quantum dots (BPQDs), low‐melting agarose, polyvinylpyrrolidone (PVP), and triamcinolone acetonide (TA). Among them, the soluble HA serves as a long‐term moisturizer for relieving dryness symptoms of AD. By introducing the NIR excitable and photothermal responsive BPQDs into agarose, the state of the composite material can be adjusted intelligently via NIR, thus achieving controllable release of the encapsulated TA in tips. Besides, PVP with enough mechanical strength can help MNs successfully penetrate the thickened skin of AD patients. Based on these advantages, it is demonstrated that the multifunctional MN patch reveals a satisfactory therapeutic effect in the AD model of Balb/c mice. These results indicate the potential values of the proposed MN patch in the treatment of AD skin diseases and other related biomedical fields. The near‐infrared responsive microneedle (MN) patch integrates with moisturizing backing and intelligent drug release tips, which can achieve a long‐term moisturizing effect and controllably deliver triamcinolone acetonide into the skin. Such MN patch exhibits a satisfactory treatment effect in atopic dermatitis‐modeled mice, which indicates that the multifunctional MN patch can potentially serve as a candidate for atopic dermatitis therapy.
ISSN:2688-4062
2688-4062
DOI:10.1002/sstr.202400302