Cardiovascular disease and bone health in aging female rheumatic disease populations: A review

Rheumatic diseases cover a wide spectrum of conditions, including primary and secondary degenerative joint diseases and autoimmune inflammatory rheumatic diseases. The risks of cardiovascular disease and osteoporosis and resultant fractures in aging female rheumatic disease populations, especially t...

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Bibliographic Details
Published in:Women's Health 2023-01, Vol.19, p.17455057231155286-17455057231155286
Main Authors: Cabling, Marven G, Sandhu, Vaneet K, Downey, Christina D, Torralba, Karina D
Format: Article
Language:English
Subjects:
Adaptive immunity
Aging
Arthritis
Arthritis - complications
Autoimmune diseases
Autoimmune Diseases - complications
Bone
Bone Density
Cardiovascular and Metabolic Bone Health in Aging Women
Cardiovascular diseases
Cardiovascular Diseases - complications
Degeneration
Female
Fractures
Health risks
Humans
Immune system
Immunosenescence
Immunosuppressive agents
Innate immunity
Joint diseases
Joints (anatomy)
Osteoporosis
Osteoporosis - complications
Populations
Rheumatic diseases
Rheumatic Diseases - complications
Womens health
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Summary:Rheumatic diseases cover a wide spectrum of conditions, including primary and secondary degenerative joint diseases and autoimmune inflammatory rheumatic diseases. The risks of cardiovascular disease and osteoporosis and resultant fractures in aging female rheumatic disease populations, especially those with autoimmune rheumatic diseases, are increased. Changes in the immune system in aging populations need to be considered especially among patients with autoimmune rheumatic diseases. Immunosenescence is closely aligned to reduced adaptive immunity and increased non-specific innate immunity leading to chronic inflammation of inflammaging. The effective use of disease-modifying antirheumatic drugs to control autoimmune rheumatic diseases may also mitigate factors leading to cardiovascular disease and osteoporosis. Rheumatic diseases, which largely manifest as arthritis, predispose patients to premature joint degeneration and poor bone health and therefore have a higher risk of developing end-stage arthritis requiring joint arthroplasties sooner or more often than other patients without rheumatic disease.
ISSN:1745-5057
1745-5065
DOI:10.1177/17455057231155286