The role of 'paraoxonase-1 activity' as an antioxidant in coronary artery diseases

A majority of the Coronary Artery Diseases (CAD) result from complications of atherosclerosis. There is a growing body of evidence which has revealed that the reduced activity of the HDL-associated enzyme, paraoxonase1 (PON1), is predictive of vascular disease in humans, which include the results fr...

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Bibliographic Details
Published in:Journal of clinical and diagnostic research 2013-07, Vol.7 (7), p.1284-1287
Main Authors: Shekhanawar, Maharudra, Shekhanawar, Sarala M, Krisnaswamy, D, Indumati, V, Satishkumar, D, Vijay, V, Rajeshwari, T, Amareshwar, M
Format: Article
Language:English
Subjects:
antioxidants
coronary artery disease
Original
oxidative stress
paraoxonase1
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Summary:A majority of the Coronary Artery Diseases (CAD) result from complications of atherosclerosis. There is a growing body of evidence which has revealed that the reduced activity of the HDL-associated enzyme, paraoxonase1 (PON1), is predictive of vascular disease in humans, which include the results from prospective studies. The mechanisms by which PON1 activity influences risk of vascular disease continue to be evaluated. It is generally thought that PON1 contributes to the antioxidant, and thus, to the antiatherogenic properties of High Density Lipoproteins (HDL). Depleted antioxidant levels could be a risk factor for coronary artery disease. Hence, this study was done to evaluate PON1, as antioxidant, in CAD patients. This study was done to determine serum levels of PON1 activity in 50 controls and in 60 clinically and ECG proven CAD cases and to compare PON1 activity with total cholesterol and triglycerides. Serum levels of PON1 activity (p
ISSN:2249-782X
0973-709X
DOI:10.7860/JCDR/2013/5144.3118