Aberrant Histone Methylation in Patients with Graves’ Disease

Background. Graves’ disease (GD) is an organ-specific autoimmune disease. Accumulated data have indicated that aberrant epigenetic modifications are associated with many autoimmune disorders. However, it remains unknown whether histone methylation plays a role in the pathogenesis of GD. In the prese...

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Bibliographic Details
Published in:International journal of endocrinology 2019-01, Vol.2019 (2019), p.1-7
Main Authors: Zhang, Jin-an, Shao, Xiao-qing, Song, Rong-hua, Qin, Qiu, Li, Ling, An, Xiaofei, Mu, Kaida, Yan, Ni, Yao, Qiu-ming
Format: Article
Language:English
Subjects:
Antibodies
Autoimmune diseases
Deoxyribonucleic acid
Disease
DNA
DNA methylation
Endocrinology
Epigenetic inheritance
Epigenetics
Gene expression
Genes
Goiter
Hyperthyroidism
Laboratories
Methylation
Methyltransferases
Pathogenesis
Proteins
RNA
Thyroid gland
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Summary:Background. Graves’ disease (GD) is an organ-specific autoimmune disease. Accumulated data have indicated that aberrant epigenetic modifications are associated with many autoimmune disorders. However, it remains unknown whether histone methylation plays a role in the pathogenesis of GD. In the present study, we aimed to assess histone modification patterns in peripheral blood mononuclear cells (PBMCs) from GD patients. The rate (degree) of H3K4 and H3K9 methylation and the expressions of histone-modifying genes were investigated. Methods. A total of 68 GD patients and 32 healthy controls were enrolled in this study. Global histone H3K4/H3K9 methylation of PBMCs was evaluated by the EpiQuik™ global histone H3K4/H3K9 methylation assay kit. The expressions of histone methyltransferases (HMTs) and histone demethylases (HDMs) at the mRNA level were determined by real-time quantitative polymerase chain reaction. Results. Global histone H3K9 methylation in PBMCs of GD patients was significantly decreased compared with that in the healthy controls (P=0.007). The expressions of HMTs (SUV39H1 and SUV39H2) at the mRNA level were significantly decreased in PBMCs from GD patients compared with healthy controls (P
ISSN:1687-8337
1687-8345
DOI:10.1155/2019/1454617