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A simple and efficient approach to the synthesis of 2-substituted benzimidazole via sp3 C–H functionalization

A facile and novel approach to the synthesis of 2-substituted benzimidazole was developed via a tandem reaction following sp3 C–H functionalization. Here we report a simple, efficient and tandem oxidative dehydrative coupling reaction of N-benzylbezene-1,2-diamine in the presence of oxidant tert-but...

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Bibliographic Details
Published in:Arabian journal of chemistry 2016-09, Vol.9 (S1), p.S515-S521
Main Authors: Patil, Sachin V., Patil, Sachin S., Bobade, Vivek D.
Format: Article
Language:English
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Summary:A facile and novel approach to the synthesis of 2-substituted benzimidazole was developed via a tandem reaction following sp3 C–H functionalization. Here we report a simple, efficient and tandem oxidative dehydrative coupling reaction of N-benzylbezene-1,2-diamine in the presence of oxidant tert-butyl hydroperoxide (TBHP) in solvent acetonitrile to give substituted benzimidazole.
ISSN:1878-5352
1878-5379
DOI:10.1016/j.arabjc.2011.06.017