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A simple and efficient approach to the synthesis of 2-substituted benzimidazole via sp3 C–H functionalization
A facile and novel approach to the synthesis of 2-substituted benzimidazole was developed via a tandem reaction following sp3 C–H functionalization. Here we report a simple, efficient and tandem oxidative dehydrative coupling reaction of N-benzylbezene-1,2-diamine in the presence of oxidant tert-but...
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Published in: | Arabian journal of chemistry 2016-09, Vol.9 (S1), p.S515-S521 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | A facile and novel approach to the synthesis of 2-substituted benzimidazole was developed via a tandem reaction following sp3 C–H functionalization. Here we report a simple, efficient and tandem oxidative dehydrative coupling reaction of N-benzylbezene-1,2-diamine in the presence of oxidant tert-butyl hydroperoxide (TBHP) in solvent acetonitrile to give substituted benzimidazole. |
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ISSN: | 1878-5352 1878-5379 |
DOI: | 10.1016/j.arabjc.2011.06.017 |