Research progress on the pathogenesis of Graves’ ophthalmopathy: Based on immunity, noncoding RNA and exosomes

Graves’ ophthalmopathy (GO), also known as thyroid-associated ophthalmopathy, is a common potentially vision-threatening organ-specific autoimmune disease and the most common extrathyroidal manifestation of Graves’ disease. It can happen to those who have hyperthyroidism or euthyroidism. At present,...

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Bibliographic Details
Published in:Frontiers in immunology 2022-08, Vol.13, p.952954-952954
Main Authors: Zheng, Jingyi, Duan, Honghong, You, Sufang, Liang, Bo, Chen, Yuping, Huang, Huibin
Format: Article
Language:English
Subjects:
autoantigen
biologics
cellular immunity
exosomes
Graves’ ophthalmopathy
Immunology
noncoding RNA
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Summary:Graves’ ophthalmopathy (GO), also known as thyroid-associated ophthalmopathy, is a common potentially vision-threatening organ-specific autoimmune disease and the most common extrathyroidal manifestation of Graves’ disease. It can happen to those who have hyperthyroidism or euthyroidism. At present, the pathogenesis of GO has not been fully elucidated, and the majority of clinical treatments are symptomatic. Therefore, we are eager to discover any new therapeutic strategies that target the etiology of GO. To provide fresh ideas for the creation of new therapeutic techniques, this study primarily discusses the research state and progress of GO-related pathogenesis from the perspectives of GO’s cellular immunity, autoantigens, non-coding RNAs, and exosomes.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.952954