Epidermal Growth Factor Receptor Expression in Esophageal Adenocarcinoma : Relationship with Tumor Stage and Survival after Esophagectomy

Background and Aims. Esophageal adenocarcinoma (EA) is an aggressive tumor with increasing incidence in occidental countries. Several prognostic biomarkers have been proposed, including epidermal growth factor receptor (EGFR). The aim of this study was to assess whether EGFR expression predicts EA s...

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Bibliographic Details
Published in:Gastroenterology research and practice 2012-01, Vol.2012 (2012), p.1-5
Main Authors: Gurski, Richard Ricachenevski, Navarini, Daniel, Madalosso, Carlos Augusto, Aita, Lucas, Meurer, Luise, Fornari, Fernando
Format: Article
Language:English
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Summary:Background and Aims. Esophageal adenocarcinoma (EA) is an aggressive tumor with increasing incidence in occidental countries. Several prognostic biomarkers have been proposed, including epidermal growth factor receptor (EGFR). The aim of this study was to assess whether EGFR expression predicts EA staging and patient survival. Methods. In this historical cohort, consecutive patients with EA managed between 2000 and 2010 were considered eligible for the study. Surgical specimens of patients treated with transhiatal esophagectomy were evaluated to establish EGFR expression and tumor differentiation. Staging was classified according with tumor-node-metastasis (TNM) system. Survival was determined according to either medical register or patient’s family contact. Results. Thirty-seven patients who underwent esophagectomy without presurgical chemotherapy or radiotherapy were studied. EGFR expression was found in 16 patients (43%). EGFR expression was more frequent as higher was the TNM (I and II=0% versus III=47% versus IV=100%; P
ISSN:1687-6121
1687-630X
DOI:10.1155/2012/941954