Citrullus colocynthis (L.) Schrad.: A Promising Pharmaceutical Resource for Multiple Diseases

Citrullus colocynthis (L.) Schrad. (Cucurbitaceae) is widely distributed in the desert areas of the world. The fruit bodies of C. colocynthis are recognized for their wide range of nutraceutical potential, as well as medicinal and pharmaceutical uses. The plant has been reported for various uses, su...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2023-08, Vol.28 (17), p.6221
Main Authors: Cheng, Xiaotian, Qin, Minni, Chen, Rongrong, Jia, Yunxia, Zhu, Qing, Chen, Guangtong, Wang, Andong, Ling, Bai, Rong, Weiwei
Format: Article
Language:English
Subjects:
antidiabetic effect
Antidiabetics
antitumor
Arthritis
Asthma
Cancer
Cell cycle
Citrullus colocynthis (L.) Schrad
Cucurbitaceae
Cytotoxicity
Diabetes
Flavonoids
Flowers & plants
Fruits
Inflammatory bowel disease
insecticide
Insecticides
Phytochemicals
Review
Seeds
Toxicity
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container_title Molecules (Basel, Switzerland)
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description Citrullus colocynthis (L.) Schrad. (Cucurbitaceae) is widely distributed in the desert areas of the world. The fruit bodies of C. colocynthis are recognized for their wide range of nutraceutical potential, as well as medicinal and pharmaceutical uses. The plant has been reported for various uses, such as asthma, bronchitis, cancer, colic, common cold, cough, diabetes, dysentery, and jaundice. The fruit has been extensively studied for its biological activities, which include insecticide, antitumor, and antidiabetic effects. Numerous bioactive compounds have been reported in its fruit bodies, such as essential oils, fatty acids, glycosides, alkaloids, and flavonoids. Of these, flavonoids or caffeic acid derivatives are the constituents associated with the inhibition of fungal or bacterial growth, whereas eudesmane sesquiterpenes or sesquiterpene lactones are most active against insects, mites, and nematodes. In this review, the scientific evidence for the biological activity of C. colocynthis against insecticide, cytotoxic, and antidiabetic effects is summarized.
doi_str_mv 10.3390/molecules28176221
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subjects antidiabetic effect
Antidiabetics
antitumor
Arthritis
Asthma
Cancer
Cell cycle
Citrullus colocynthis (L.) Schrad
Cucurbitaceae
Cytotoxicity
Diabetes
Flavonoids
Flowers & plants
Fruits
Inflammatory bowel disease
insecticide
Insecticides
Phytochemicals
Review
Seeds
Toxicity
title Citrullus colocynthis (L.) Schrad.: A Promising Pharmaceutical Resource for Multiple Diseases
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