Acceleration of Wound Healing in Rats by Modified Lignocellulose Based Sponge Containing Pentoxifylline Loaded Lecithin/Chitosan Nanoparticles

Dressing wounds accelerates the re-epithelialization process and changes the inflammatory environment towards healing. In the current study, a lignocellulose sponge containing pentoxifylline (PTX)-loaded lecithin/chitosan nanoparticles (LCNs) was developed to enhance the wound healing rate. Lecithin...

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Bibliographic Details
Published in:Gels 2022-10, Vol.8 (10), p.658
Main Authors: Dehghani, Pouya, Akbari, Aliakbar, Saadatkish, Milad, Varshosaz, Jaleh, Kouhi, Monireh, Bodaghi, Mahdi
Format: Article
Language:English
Subjects:
Biocompatibility
Care and treatment
Cellulose
Chemical bonds
Chitosan
Gene expression
Hydrogels
Lecithin
Lignocellulose
modified lignocellulose
Nanoparticles
Oxidation
Particle size distribution
Pentoxifylline
rat model
Spectrum analysis
Sponges
Sustained release
Visual observation
wound dressing
Wound healing
Wounds and injuries
Zeta potential
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Summary:Dressing wounds accelerates the re-epithelialization process and changes the inflammatory environment towards healing. In the current study, a lignocellulose sponge containing pentoxifylline (PTX)-loaded lecithin/chitosan nanoparticles (LCNs) was developed to enhance the wound healing rate. Lecithin/chitosan nanoparticles were obtained by the solvent-injection method and characterized in terms of morphology, particle size distribution, and zeta potential. The lignocellulose hydrogels were functionalized through oxidation/amination and freeze-dried to obtain sponges. The prepared sponge was then loaded with LCNs/PTX to control drug release. The nanoparticle containing sponges were characterized using FTIR and SEM analysis. The drug release study from both nanoparticles and sponges was performed in PBS at 37 °C at different time points. The results demonstrated that PTX has sustained release from lignocellulose hydrogels. The wound healing was examined using a standard rat model. The results exhibited that PTX loaded hydrogels could achieve significantly accelerated and enhanced healing compared to the drug free hydrogels and the normal saline treatment. Histological examination of the healed skin confirmed the visual observations. Overall speaking, the in vivo assessment of the developed sponge asserts its suitability as wound dressing for treatment of chronic skin wounds.
ISSN:2310-2861
2310-2861
DOI:10.3390/gels8100658