Reactive Metabolites and AGE-RAGE-Mediated Inflammation in Patients following Liver Transplantation

Recent investigations have indicated that reactive metabolites and AGE-RAGE-mediated inflammation might play an important role in the pathogenesis of ischemia-reperfusion injury in liver transplantation. In this observational clinical study, 150 patients were enrolled following liver transplantation...

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Bibliographic Details
Published in:Mediators of Inflammation 2013-01, Vol.2013 (2013), p.756-765-168
Main Authors: Brenner, Thorsten, Fleming, Thomas H., Spranz, David, Schemmer, Peter, Bruckner, Thomas, Uhle, Florian, Martin, Eike, Weigand, Markus A., Hofer, Stefan
Format: Article
Language:English
Subjects:
Antioxidants - metabolism
Arginine - analogs & derivatives
Arginine - blood
Clinical Study
Female
Glycation End Products, Advanced - blood
Humans
Inflammation
Inflammation - metabolism
Liver
Liver Transplantation - adverse effects
Male
Medical research
Medicine, Experimental
Metabolism
Models, Biological
Physiological aspects
Pyruvaldehyde - blood
Receptor for Advanced Glycation End Products
Receptors, Immunologic - blood
Transplantation
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Summary:Recent investigations have indicated that reactive metabolites and AGE-RAGE-mediated inflammation might play an important role in the pathogenesis of ischemia-reperfusion injury in liver transplantation. In this observational clinical study, 150 patients were enrolled following liver transplantation from deceased donors. The occurrence of short-term complications within 10 days of transplantation was documented. Blood samples were collected prior to transplantation, immediately after transplantation, and at consecutive time points, for a total of seven days after transplantation. Plasma levels of methylglyoxal were determined using HPLC, whereas plasma levels of L-arginine, asymmetric dimethylarginine, advanced glycation endproducts-carboxylmethyllysine, soluble receptor for advanced glycation endproducts, and total antioxidant capacity were measured by ELISA. Patients following liver transplantation were shown to suffer from increased RAGE-associated inflammation with an AGE load mainly dependent upon reactive carbonyl species-derived AGEs. In contrast, carboxylmethyllysine-derived AGEs were of a minor importance. As assessed by the ratio of L-arginine/asymmetric dimethylarginine, the bioavailability of nitric oxide was shown to be reduced in hepatic IRI, especially in those patients suffering from perfusion disorders following liver transplantation. For the early identification of patients at high risk of perfusion disorders, the implementation of asymmetric dimethylarginine measurements in routine diagnostics following liver transplantation from deceased donors should be taken into consideration.
ISSN:0962-9351
1466-1861
DOI:10.1155/2013/501430