Inhibitory effects of constituents from Morus alba var. multicaulis on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells

A new arylbenzofuran, 3',5'-dihydroxy-6-methoxy-7-prenyl-2-arylbenzofuran (1), and 25 known compounds, including moracin R (2), moracin C (3), moracin O (4), moracin P (5), artoindonesianin O (6), moracin D (7), alabafuran A (8), mulberrofuran L (9), mulberrofuran Y (10), kuwanon A (11), k...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2011-07, Vol.16 (7), p.6010-6022
Main Authors: Yang, Zhi-Gang, Matsuzaki, Keiichi, Takamatsu, Satoshi, Kitanaka, Susumu
Format: Article
Language:English
Subjects:
3T3-L1 Cells
Acids
Adenosine
adipocyte
Adipocytes
Adipocytes - cytology
Adipocytes - drug effects
Animals
arylbenzofuran
Benzofurans - chemistry
Benzofurans - pharmacology
Body fat
Cell Differentiation - drug effects
Cell Line
Flavonoids
Flavonoids - chemistry
Flavonoids - pharmacology
Glycerol
Inflammation
macrophage
Macrophages - drug effects
Macrophages - metabolism
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Morus - chemistry
Morus alba var. multicaulis Perro
Nitric oxide
Nitric Oxide - metabolism
Obesity
Plant Extracts - chemistry
Plant Extracts - pharmacology
prenyl-flavonoid
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Summary:A new arylbenzofuran, 3',5'-dihydroxy-6-methoxy-7-prenyl-2-arylbenzofuran (1), and 25 known compounds, including moracin R (2), moracin C (3), moracin O (4), moracin P (5), artoindonesianin O (6), moracin D (7), alabafuran A (8), mulberrofuran L (9), mulberrofuran Y (10), kuwanon A (11), kuwanon C (12), kuwanon T (13), morusin (14), kuwanon E (15), sanggenon F (16), betulinic acid (17), uvaol (18), ursolic acid (19), β-sitosterol (20), oxyresveratrol 2-O-β-D-glucopyranoside (21), mulberroside A (22), mulberroside B (23), 5,7-dihydroxycoumarin 7-O-β-D-glucopyranoside (24), 5,7-dihydroxycoumarin 7-O-β-D-apiofuranosyl-(1→6)-O-β-D-glucopyranoside (25) and adenosine (26), were isolated from Morus alba var. multicaulis Perro. (Moraceae). Their structures were determined by spectroscopic methods. The prenyl-flavonoids 11-14, 16, triterpenoids 17,18 and 20 showed significant inhibitory activity towards the differentiation of 3T3-L1 adipocytes. The arylbenzofurans 1-10 and prenyl-flavonoids 11-16 also showed significant nitric oxide (NO) production inhibitory effects in RAW264.7 cells.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules16076010