Sustainable production of dopamine hydrochloride from softwood lignin

Dopamine is not only a widely used commodity pharmaceutical for treating neurological diseases but also a highly attractive base for advanced carbon materials. Lignin, the waste from the lignocellulosic biomass industry, is the richest source of renewable aromatics on earth. Efficient production of...

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Bibliographic Details
Published in:Nature communications 2023-08, Vol.14 (1), p.4996-4996, Article 4996
Main Authors: Dong, Lin, Wang, Yanqin, Dong, Yuguo, Zhang, Yin, Pan, Mingzhu, Liu, Xiaohui, Gu, Xiaoli, Antonietti, Markus, Chen, Zupeng
Format: Article
Language:English
Subjects:
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Amination
Aromatic compounds
Depolymerization
Dopamine
Economic analysis
Humanities and Social Sciences
Lignin
Lignocellulose
multidisciplinary
Neurological diseases
Science
Science (multidisciplinary)
Softwoods
Strategy
Sustainability
Sustainable development
Sustainable production
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Summary:Dopamine is not only a widely used commodity pharmaceutical for treating neurological diseases but also a highly attractive base for advanced carbon materials. Lignin, the waste from the lignocellulosic biomass industry, is the richest source of renewable aromatics on earth. Efficient production of dopamine direct from lignin is a highly desirable target but extremely challenging. Here, we report an innovative strategy for the sustainable production of dopamine hydrochloride from softwood lignin with a mass yield of 6.4 wt.%. Significantly, the solid dopamine hydrochloride is obtained by a simple filtration process in purity of 98.0%, which avoids the tedious separation and purification steps. The approach begins with the acid-catalyzed depolymerization, followed by deprotection, hydrogen-borrowing amination, and hydrolysis of methoxy group, transforming lignin into dopamine hydrochloride. The technical economic analysis predicts that this process is an economically competitive production process. This study fulfills the unexplored potential of dopamine hydrochloride synthesis from lignin. Efficient production of dopamine direct from lignin is a highly desirable target but extremely challenging. Here, we report an innovative strategy for the sustainable production of dopamine hydrochloride from softwood lignin with a mass yield of 6.4 wt.%.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-023-40702-2