Glycomimetic Peptides as Therapeutic Tools

The entry of peptides into glycobiology has led to the development of a unique class of therapeutic tools. Although numerous and well-known peptides are active as endocrine regulatory factors that bind to specific receptors, and peptides have been used extensively as epitopes for vaccine production,...

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Bibliographic Details
Published in:Pharmaceutics 2023-02, Vol.15 (2), p.688
Main Authors: Hoober, J Kenneth, Eggink, Laura L
Format: Article
Language:English
Subjects:
Analysis
Antibodies
Binding sites
Cell membranes
CLEC10A
Crystal structure
dose response
eczema
glycomimetic peptides
Health aspects
Homeostasis
Immune response
Immune system
Lectins
Libraries
Ligands
Peptides
Physiological aspects
Physiology
Proteins
Review
Sugar
transglutaminase 2
Vaccines
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Summary:The entry of peptides into glycobiology has led to the development of a unique class of therapeutic tools. Although numerous and well-known peptides are active as endocrine regulatory factors that bind to specific receptors, and peptides have been used extensively as epitopes for vaccine production, the use of peptides that mimic sugars as ligands of lectin-type receptors has opened a unique approach to modulate activity of immune cells. Ground-breaking work that initiated the use of peptides as tools for therapy identified sugar mimetics by screening phage display libraries. The peptides that have been discovered show significant potential as high-avidity, therapeutic tools when synthesized as multivalent structures. Advantages of peptides over sugars as drugs for immune modulation will be illustrated in this review.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics15020688