A rare case of vasculitis in cystic fibrosis: A clinical case

Cystic fibrosis is known to cause serious complications, such as recurrent pulmonary infections, pancreatic insufficiency, and other symptoms related to exocrine gland dysfunction. A rare manifestation of the disease is discussed in this case of a 24-year-old female diagnosed with cystic fibrosis, a...

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Bibliographic Details
Published in:Respiratory medicine case reports 2023-01, Vol.42, p.101816, Article 101816
Main Authors: Nasreddine, Sabrina, Issa, Mitchelle, Bacha, Zeina Aoun
Format: Article
Language:English
Subjects:
Bronchiectasis
Case Report
Colchicine
Cystic fibrosis
Leukocytoclastic vasculitis
Purpuric rash
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Summary:Cystic fibrosis is known to cause serious complications, such as recurrent pulmonary infections, pancreatic insufficiency, and other symptoms related to exocrine gland dysfunction. A rare manifestation of the disease is discussed in this case of a 24-year-old female diagnosed with cystic fibrosis, a purpuric rash was documented during pulmonary infection flares. Skin biopsy shows a leukocytoclastic vasculitis eruption along with infection. Treatment options are limited and not well established. Our patient received a treatment based on colchicine 1mg per day with a total response. The patient was observed during two consecutive pulmonary infection flares separated by a few months, and a total remission without recurrence was found. Considering its efficacy and safety, further scientific research about colchicine and vasculitis in cystic fibrosis should be aimed at in order to define a strong consensus between the disease and this treatment option.
ISSN:2213-0071
2213-0071
DOI:10.1016/j.rmcr.2023.101816