Borneol, a messenger agent, improves central nervous system drug delivery through enhancing blood-brain barrier permeability: a preclinical systematic review and meta-analysis

To achieve sufficient blood-brain barrier (BBB), penetration is one of the biggest challenges in the development of diagnostic and therapeutic for central nervous system (CNS) disorders. Here, we conducted a systematic review and meta-analysis to assess the preclinical evidence and possible mechanis...

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Bibliographic Details
Published in:Drug delivery 2018, Vol.25 (1), p.1617-1633
Main Authors: Zheng, Qun, Chen, Zi-Xian, Xu, Meng-Bei, Zhou, Xiao-Li, Huang, Yue-Yue, Zheng, Guo-Qing, Wang, Yan
Format: Article
Language:English
Subjects:
Animals
Blood-brain barrier
Blood-Brain Barrier - metabolism
Bornanes - chemistry
Borneol
Brain research
Cardiology
Central Nervous System Agents - pharmacology
Central Nervous System Diseases - drug therapy
Drug Carriers - chemistry
drug delivery
Drug delivery systems
Drugs
Female
Glycoproteins
Hospitals
Humans
Male
Meta-analysis
Nervous system
Permeability
possible mechanisms
preclinical evidence
Studies
Systematic review
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Summary:To achieve sufficient blood-brain barrier (BBB), penetration is one of the biggest challenges in the development of diagnostic and therapeutic for central nervous system (CNS) disorders. Here, we conducted a systematic review and meta-analysis to assess the preclinical evidence and possible mechanisms of borneol for improving co-administration of CNS drug delivery in animal models. The electronic literature search was conducted in six databases. Fifty-eight studies with 63 comparisons involved 1137 animals were included. Among 47 studies reporting the assessments of CNS drug concentration, 45 studies showed the significant effects of borneol for improving CNS drug delivery (p.05). Nineteen comparisons showed borneol up-regulated BBB permeability (p .05). Effects of borneol are closely associated with inhibition of efflux protein function, releasement of tight junction protein, increasement of vasodilatory neurotransmitters, and inhibition of active transport by ion channels. In conclusion, borneol is a promising candidate for CNS drug delivery, mainly through mediating a multi-targeted BBB permeability.
ISSN:1071-7544
1521-0464
DOI:10.1080/10717544.2018.1486471