Dysregulation of iron metabolism modulators in virologically suppressed HIV-infected patients

Iron metabolism plays an essential role in cellular functions. Since virologically suppressed chronic HIV-infected subjects under effective antiretroviral treatment (ART) exhibit a persistent immune dysfunction that leads to comorbidities, iron homeostasis may be relevant in this context. We aimed t...

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Published in:Frontiers in immunology 2022-11, Vol.13, p.977316-977316
Main Authors: Garrido-Rodríguez, Vanesa, Álvarez-Ríos, Ana Isabel, Olivas-Martínez, Israel, Pozo-Balado, María Del Mar, Bulnes-Ramos, Ángel, Leal, Manuel, Pacheco, Yolanda María
Format: Article
Language:English
Subjects:
Adult
Aged
Anemia, Iron-Deficiency
Anti-Retroviral Agents - therapeutic use
chronic HIV infection
Female
Ferritins
hepcidin
Humans
Immunology
inflammation
Iron
Iron Deficiencies
iron metabolism
Male
Middle Aged
Receptors, Transferrin
Retrospective Studies
soluble transferrin receptor
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Summary:Iron metabolism plays an essential role in cellular functions. Since virologically suppressed chronic HIV-infected subjects under effective antiretroviral treatment (ART) exhibit a persistent immune dysfunction that leads to comorbidities, iron homeostasis may be relevant in this context. We aimed to explore iron metabolism in virologically suppressed chronic HIV infected subjects under a successful ART. In this retrospective study, traditional iron metabolism biomarkers (total iron, ferritin, transferrin, and transferrin saturation index), as well as soluble transferrin receptor (sTfR), hepcidin, and inflammatory markers were determined in virologically suppressed chronic HIV-infected subjects under at least 2 years of ART (HIV) who also had >350 CD4-T-cells/mm (N=92) from Spain. As controls, we collected non-HIV age-matched healthy donors (Young, N=25) and elderly subjects (>65 years old; Elderly; N=25). Additionally, an external group of non-HIV patients with ferritin
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.977316