Effect of topical 0.05% cyclosporine A on the tear protein lacritin in a rat model of dry eye

To observe the effect of topical 0.05% cyclosporine A (CsA) on the ocular surface and tear protein lacritin in a botulinum B-induced dry eye rat model. A total of 36 female SD rats were randomly divided into 3 groups, botulinum B was injected into the right lacrimal gland of all rats. Group A and gr...

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Bibliographic Details
Published in:International journal of ophthalmology 2019-02, Vol.12 (2), p.189-193
Main Authors: Zhang, Fen-Dui, Hao, Zhao-Qin, Gao, Wei, Xing, Yi-Qiao
Format: Article
Language:English
Subjects:
0.05% cyclosporine a
Basic Research
dry eye
tear protein lacritin
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Summary:To observe the effect of topical 0.05% cyclosporine A (CsA) on the ocular surface and tear protein lacritin in a botulinum B-induced dry eye rat model. A total of 36 female SD rats were randomly divided into 3 groups, botulinum B was injected into the right lacrimal gland of all rats. Group A and group B were treated with 0.05% CsA and 0.1% sodium hyaluronate, respectively, 3 times daily. The control group was not treated. Basal tear flow, corneal epithelial defects, and lacritin levels were measured. Tear secretion in all rats was reduced on day 3 and was even lower on day 7 postoperation (
ISSN:2222-3959
2227-4898
DOI:10.18240/ijo.2019.02.01