Body composition changes differ by gender in stomach, colorectal, and biliary cancer patients with cachexia: Results from a pilot study

Few studies have examined the possibility that cachexia may affect men and women differently. This pilot study assessed gender differences in body composition in stomach, colorectal, and biliary cancer patients with cachexia. A sample of 38 participants (Female: Male = 17:21, mean age 57.4 years) we...

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Published in:Cancer medicine (Malden, MA) MA), 2018-08, Vol.7 (8), p.3695-3703
Main Authors: Yoon, Saunjoo L., Grundmann, Oliver, Williams, Joseph J., Gordan, Lucio, George, Thomas J.
Format: Article
Language:English
Subjects:
Adult
Aged
Biliary Tract Neoplasms - complications
Biliary Tract Neoplasms - diagnosis
bioelectrical impedance analysis
Body Composition
Body weight loss
Cachexia
Cachexia - diagnosis
Cachexia - etiology
Cancer
Chemotherapy
Clinical Cancer Research
Colorectal cancer
Colorectal Neoplasms - complications
Colorectal Neoplasms - diagnosis
Female
gender
Gender differences
Humans
Male
Middle Aged
Neoplasm Staging
Original Research
phase angle
Pilot Projects
Sex differences
Sex Factors
Stomach
Stomach Neoplasms - complications
Stomach Neoplasms - diagnosis
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description Few studies have examined the possibility that cachexia may affect men and women differently. This pilot study assessed gender differences in body composition in stomach, colorectal, and biliary cancer patients with cachexia. A sample of 38 participants (Female: Male = 17:21, mean age 57.4 years) were included if they were undergoing chemotherapy and experienced weight loss of 5% or more over a 6‐month period. Bioelectrical impedance analysis (BIA) was applied to measure body composition. Phase angle (PA) and levels of extra‐/intracellular water (ECW; ICW) were determined. Data were analyzed first by gender and then compared to age‐ and gender‐matched healthy controls from the NHANES‐III dataset. PA was lower (P 
doi_str_mv 10.1002/cam4.1665
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This pilot study assessed gender differences in body composition in stomach, colorectal, and biliary cancer patients with cachexia. A sample of 38 participants (Female: Male = 17:21, mean age 57.4 years) were included if they were undergoing chemotherapy and experienced weight loss of 5% or more over a 6‐month period. Bioelectrical impedance analysis (BIA) was applied to measure body composition. Phase angle (PA) and levels of extra‐/intracellular water (ECW; ICW) were determined. Data were analyzed first by gender and then compared to age‐ and gender‐matched healthy controls from the NHANES‐III dataset. PA was lower (P &lt; .01) in both genders compared with healthy controls, and PA was lower in female patients compared with male patients (P = .03). Male cancer patients with lower PA also had lower ICW levels compared with healthy controls (r = .98, P &lt; .01). For female patients, PA and ICW were negatively correlated (r = .897, P &lt; .01). 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subjects Adult
Aged
Biliary Tract Neoplasms - complications
Biliary Tract Neoplasms - diagnosis
bioelectrical impedance analysis
Body Composition
Body weight loss
Cachexia
Cachexia - diagnosis
Cachexia - etiology
Cancer
Chemotherapy
Clinical Cancer Research
Colorectal cancer
Colorectal Neoplasms - complications
Colorectal Neoplasms - diagnosis
Female
gender
Gender differences
Humans
Male
Middle Aged
Neoplasm Staging
Original Research
phase angle
Pilot Projects
Sex differences
Sex Factors
Stomach
Stomach Neoplasms - complications
Stomach Neoplasms - diagnosis
title Body composition changes differ by gender in stomach, colorectal, and biliary cancer patients with cachexia: Results from a pilot study
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