Involvement of YKL-40-positive macrophages commonly identified in polymyositis and dermatomyositis in the pathogenesis of myositis: a retrospective study

YKL-40 is implicated in inflammation and tissue repair, but no reports have investigated its involvement in myositis in polymyositis (PM) and dermatomyositis (DM). Therefore, we aimed to investigate the relationship between YKL-40 and PM/DM. We retrospectively enrolled 35 patients diagnosed with PM/...

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Bibliographic Details
Published in:Immunological medicine 2024-03, Vol.47 (1), p.37-44
Main Authors: Noguchi, Kazuteru, Furukawa, Tetsuya, Tatsumi, Yoshiki, Kasama, Shuhei, Yoshikawa, Takahiro, Hashimoto, Teppei, Azuma, Naoto, Hirota, Seiichi, Kimura, Takashi, Matsui, Kiyoshi
Format: Article
Language:English
Subjects:
Chitinase-3-Like Protein 1
Dermatomyositis
Humans
Macrophages
muscle destruction
Myositis - etiology
polymyositis
Polymyositis - diagnosis
Polymyositis - pathology
Retrospective Studies
YKL-40
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Summary:YKL-40 is implicated in inflammation and tissue repair, but no reports have investigated its involvement in myositis in polymyositis (PM) and dermatomyositis (DM). Therefore, we aimed to investigate the relationship between YKL-40 and PM/DM. We retrospectively enrolled 35 patients diagnosed with PM/DM along with 26 healthy controls (HCs). Both PM and DM were diagnosed according to Bohan and Peter's criteria. Serum YKL-40 levels were measured, age-corrected to YKL-40 percentile values, and compared to HCs. Patients with myositis without interstitial lung disease were also enrolled and compared to HCs. Immunofluorescence staining was performed to identify YKL-40-positive inflammatory cells in muscle biopsy samples from two patients each with PM and DM. Age-corrected serum YKL-40 levels were significantly higher in patients with PM/DM compared to HCs with and without lung disease; however, these levels decreased significantly after treatment. Immunohistochemical analysis showed infiltration of YKL-40-positive inflammatory cells into the intramuscular sheath and perimuscular membrane. Immunofluorescence staining showed CD68 expression in YKL-40-positive inflammatory cells, suggesting that these cells were macrophages. To the best of our knowledge, this is the first study to demonstrate that YKL-40-positive macrophages are present in PM and DM, indicating that YKL-40 may be involved in PM/DM.
ISSN:2578-5826
2578-5826
DOI:10.1080/25785826.2023.2264007