Injectable Composite Systems of Gellan Gum:Alginate Microparticles in Pluronic Hydrogels for Bioactive Cargo Controlled Delivery: Optimization of Hydrogel Composition based on Rheological Behavior

Due to the high complexity of some treatments, there is a need to develop drug-delivery systems that can release multiple drugs/bioactive agents at different stages of treatment. In this study, a thermoresponsive injectable dual-release system was developed with gellan gum/alginate microparticles (G...

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Bibliographic Details
Published in:Fluids (Basel) 2022-12, Vol.7 (12), p.375
Main Authors: Carrêlo, Henrique, Escoval, André R, Soares, Paula I. P, Borges, João P, Cidade, Maria Teresa
Format: Article
Language:English
Subjects:
Air flow
alginate
Alginates
Aqueous solutions
Biological activity
Cancer therapies
Chemical properties
Chloride
Drug delivery systems
Drugs
Gellan gum
Health aspects
Human body
Hydrogels
Injectability
Materials
Methylene blue
Microparticles
Optimization
Pluronic
Poloxamers
Polysaccharides
Potassium
Rheological properties
Rheology
Sodium
Sol-gel processes
Temperature
thermoresponsive
Transition temperatures
Vehicles
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Summary:Due to the high complexity of some treatments, there is a need to develop drug-delivery systems that can release multiple drugs/bioactive agents at different stages of treatment. In this study, a thermoresponsive injectable dual-release system was developed with gellan gum/alginate microparticles (GG:Alg) within a thermoresponsive Pluronic hydrogel composed of a mixture of Pluronic F127 and F68. The increase in F68 ratio and decrease in F127 lead to higher transition temperatures. The addition of the GG:Alg microparticles decreased the transition temperatures with a linear tendency. In Pluronic aqueous solutions (20 wt.%), the F127:F68 ratios of 16:4 and 17:3 (wt.%:wt.%) and the addition of microparticles (up to 15 wt.%) maintained the sol–gel transition temperatures within a suitable range (between 25 °C and 37 °C). Microparticles did not hinder the injectability of the system in the sol phase. Methylene blue was used as a model drug to evaluate the release mechanisms from microparticles, hydrogel, and composite system. The hydrogel delayed the release of methylene blue from the microparticles. The hydrogel loaded with methylene blue released at a faster rate than the microparticles within the hydrogel, thus demonstrating a dual-release profile.
ISSN:2311-5521
2311-5521
DOI:10.3390/fluids7120375