Research insights into the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (CMTM): their roles in various tumors

The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing (CMTM) family includes CMTM1-8 and CKLF, and they play key roles in the hematopoietic, immune, cardiovascular, and male reproductive systems, participating in the physiological functions, cancer, and other diseases associat...

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Published in:PeerJ (San Francisco, CA) CA), 2024-01, Vol.12, p.e16757-e16757, Article e16757
Main Authors: Duan, Sai-Li, Jiang, Yingke, Li, Guo-Qing, Fu, Weijie, Song, Zewen, Li, Li-Nan, Li, Jia
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis pathway
Breast cancer
Cancer therapies
Cell cycle
Cell death
Cell growth
Cell proliferation
Chemokines
Chemokines - genetics
Chromosomes
CMTM family
Development and progression
Gastric cancer
Gene methylation
Gene therapy
Humans
Immune checkpoint
Immunotherapy
Kinases
Liver
Liver cancer
MARVEL Domain-Containing Proteins - genetics
Medical prognosis
Neoplasms - genetics
Pancreatic cancer
Patients
Physiological aspects
Plasma
Programmed death-ligand 1
Proteins
Signal Transduction
Transmembrane domains
Tumor cells
Tumorigenesis
Tumors
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Summary:The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing (CMTM) family includes CMTM1-8 and CKLF, and they play key roles in the hematopoietic, immune, cardiovascular, and male reproductive systems, participating in the physiological functions, cancer, and other diseases associated with these systems. CMTM family members activate and chemoattract immune cells to affect the proliferation and invasion of tumor cells through a similar mechanism, the structural characteristics typical of chemokines and transmembrane 4 superfamily (TM4SF). In this review, we discuss each CMTM family member's chromosomal location, involved signaling pathways, expression patterns, and potential roles, and mechanisms of action in pancreatic, breast, gastric and liver cancers. Furthermore, we discuss several clinically applied tumor therapies targeted at the CMTM family, indicating that CMTM family members could be novel immune checkpoints and potential targets effective in tumor treatment.
ISSN:2167-8359
2167-8359
DOI:10.7717/peerj.16757