Membranous Expression of Heart Development Protein with EGF-like Domain 1 Is Associated with a Good Prognosis in Patients with Bladder Cancer

Objective: To investigate the correlation between total protein expression of heart development protein with EGF-like domain 1 (HEG1) and clinicopathological characteristics in patients with bladder cancer (BC) after radical cystectomy (RC). Patients and Methods: We retrospectively analyzed data fro...

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Published in:Diagnostics (Basel) 2023-09, Vol.13 (19), p.3067
Main Authors: Mori, Kohei, Matsumoto, Kazumasa, Ikeda, Masaomi, Koguchi, Dai, Shimizu, Yuriko, Tsumura, Hideyasu, Ishii, Daisuke, Tsuji, Shoutaro, Sato, Yuichi, Iwamura, Masatsugu
Format: Article
Language:English
Subjects:
Antigens
Bladder cancer
Cancer patients
Chemotherapy
Cloning
Developmental biology
Epidermal growth factor
HEG1
Immunohistochemistry
Investigations
Kinases
Liver cancer
Medical colleges
Medical prognosis
membranous expression
Mesothelioma
Monoclonal antibodies
Mutation
Protein expression
Proteins
radical cystectomy
TCGA analysis
Tumors
Urological surgery
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Summary:Objective: To investigate the correlation between total protein expression of heart development protein with EGF-like domain 1 (HEG1) and clinicopathological characteristics in patients with bladder cancer (BC) after radical cystectomy (RC). Patients and Methods: We retrospectively analyzed data from 110 patients who underwent RC at Kitasato University Hospital. And we prepared an anti-HEG1 monoclonal antibody W10B9, which can detect total HEG1 protein. HEG1 protein expression in tumor cells was evaluated separately for membrane and cytoplasmic staining using immunohistochemistry. Results: Membranous HEG1 expression was associated with absent lymphovascular invasion (p < 0.01) and low pT stage (p < 0.01). Kaplan–Meier analysis revealed that the membranous HEG1-positive group had significantly long recurrence-free survival (RFS) (p < 0.01) and cancer-specific survival (p = 0.01). Expression of membranous HEG1 was identified as an independent prognostic factor for RFS (p = 0.04). There were no significant differences between cytoplasmic HEG1 expression and clinicopathologic factors including prognosis. Conclusion: The expression of membranous HEG1 could serve as a favorable prognostic indicator in patients with BC treated with RC.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics13193067