Ketogenic Diet and Epilepsy: What We Know So Far

The Ketogenic Diet (KD) is a modality of treatment used since the 1920s as a treatment for intractable epilepsy. It has been proposed as a dietary treatment that would produce similar benefits to fasting, which is already recorded in the Hippocratic collection. The KD has a high fat content (90%) an...

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Bibliographic Details
Published in:Frontiers in neuroscience 2019-01, Vol.13, p.5-5
Main Authors: D'Andrea Meira, Isabella, Romão, Tayla Taynan, Pires do Prado, Henrique Jannuzzelli, Krüger, Lia Theophilo, Pires, Maria Elisa Paiva, da Conceição, Priscila Oliveira
Format: Article
Language:English
Subjects:
Adolescents
Carbohydrates
Convulsions & seizures
Diet
diet therapy
Epilepsy
Fasting
High fat diet
Ketogenesis
ketogenic diet
Low carbohydrate diet
low glycemic index
Metabolism
Metabolites
modified Atkins diet
Neuroscience
Nutrient deficiency
Proteins
refractory epilepsy
Surgery
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Summary:The Ketogenic Diet (KD) is a modality of treatment used since the 1920s as a treatment for intractable epilepsy. It has been proposed as a dietary treatment that would produce similar benefits to fasting, which is already recorded in the Hippocratic collection. The KD has a high fat content (90%) and low protein and carbohydrate. Evidence shows that KD and its variants are a good alternative for non-surgical pharmacoresistant patients with epilepsy of any age, taking into account that the type of diet should be designed individually and that less-restrictive and more-palatable diets are usually better options for adults and adolescents. This review discusses the KD, including the possible mechanisms of action, applicability, side effects, and evidence for its efficacy, and for the more-palatable diets such as the Modified Atkins Diet (MAD) and the Low Glycemic Index Diet (LGID) in children and adults.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2019.00005