The mechanisms of Pin1 as targets for cancer therapy

Targeted therapy has considerable promise for the effective eradication of cancer at the primary tumor site prior to subsequent metastasis. Using this therapeutic approach, gaining an understanding of mechanistic cancer models is essential for facilitating the inhibition or suppression of tumor grow...

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Bibliographic Details
Published in:Frontiers in immunology 2024-11, Vol.15, p.1482088
Main Authors: Liu, Chuanfeng, Dan, Lingying, Li, Quan, Bajinka, Ousman, Yuan, Xingxing
Format: Article
Language:English
Subjects:
Animals
anticancer therapy
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
cis-trans structure
Humans
Immunology
Molecular Targeted Therapy
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms - therapy
NIMA-Interacting Peptidylprolyl Isomerase - antagonists & inhibitors
NIMA-Interacting Peptidylprolyl Isomerase - genetics
NIMA-Interacting Peptidylprolyl Isomerase - metabolism
peptidyl-prolyl isomerase
Phosphorylation
Pin1 inhibitor
proline
Signal Transduction - drug effects
tumorigenesis
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Summary:Targeted therapy has considerable promise for the effective eradication of cancer at the primary tumor site prior to subsequent metastasis. Using this therapeutic approach, gaining an understanding of mechanistic cancer models is essential for facilitating the inhibition or suppression of tumor growth. Among different oncogenes and proteins, the protein interacting with never-in-mitosis kinase-1 (Pin1) is particularly important. The interaction between Pin1 and phosphorylated threonine-proline motifs results in significant alterations in protein structure and function. In this review, we provide a comprehensive summary of the processes involving Pin1 and its mechanisms in the context of cancer therapy. Pin1 enhances signaling pathways in a number of different human cancers and plays a pivotal role in the suppressive mechanisms relevant to cancer treatment. It is essential for the regulation of proline-directed phosphorylation and for modulating tumor suppressors. Inhibitors of Pin1, particularly naturally occurring substances, have been found to inhibit the carcinogenic activity of Pin1, and consequently this protein could represent an excellent candidate for novel cancer treatment strategies, offering a valuable therapeutic target in carcinogenesis and treatment resistance.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2024.1482088