Circulating Tumor Cells as a Promising Tool for Early Detection of Hepatocellular Carcinoma

Liver cancer is a significant contributor to the cancer burden, and its incidence rates have recently increased in almost all countries. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and is the second leading cause of cancer-related deaths worldwide. Because of the l...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2023-09, Vol.12 (18), p.2260
Main Authors: Salehi, Mahsa, Lavasani, Zohre Miri, Keshavarz Alikhani, Hani, Shokouhian, Bahare, Hassan, Moustapha, Najimi, Mustapha, Vosough, Massoud
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Biomarkers
Biopsy
Cancer cells
Cancer therapies
circulating tumor cells
Diagnosis
early diagnosis
Epidermal growth factor
Flow cytometry
HCC biomarker
Hepatocellular carcinoma
Hepatoma
Identification and classification
Liver cancer
Medicin och hälsovetenskap
Metastasis
Physiological aspects
Review
Tumor cells
Tumors
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Summary:Liver cancer is a significant contributor to the cancer burden, and its incidence rates have recently increased in almost all countries. Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and is the second leading cause of cancer-related deaths worldwide. Because of the late diagnosis and lack of efficient therapeutic modality for advanced stages of HCC, the death rate continues to increase by ~2–3% per year. Circulating tumor cells (CTCs) are promising tools for early diagnosis, precise prognosis, and follow-up of therapeutic responses. They can be considered to be an innovative biomarker for the early detection of tumors and targeted molecular therapy. In this review, we briefly discuss the novel materials and technologies applied for the practical isolation and detection of CTCs in HCC. Also, the clinical value of CTC detection in HCC is highlighted.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells12182260