A case report of full recovery from severe cerebral edema secondary to acetaminophen-induced hepatotoxicity in a 13 year old girl

Acetaminophen is a common cause of acute liver failure in pediatrics. Cerebral edema is a significant complication of acute hepatic failure and is associated with increased mortality. We present a case of a 13 -year old girl with severe cerebral edema secondary to acetaminophen toxicity and hepatic...

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Bibliographic Details
Published in:BMC pediatrics 2018-07, Vol.18 (1), p.247-247, Article 247
Main Authors: Austin, Emily B, Hobbs, Hailey, Crouse, Brian A, Lobos, Anna-Theresa
Format: Article
Language:English
Subjects:
Acetaminophen
Acetaminophen - poisoning
Acetaminophen-induced hepatotoxicity
Adolescent
Analgesics, Non-Narcotic - poisoning
Brain - diagnostic imaging
Brain Edema - chemically induced
Brain Edema - diagnostic imaging
Brain Edema - therapy
Care and treatment
Case Report
Case reports
Cerebral edema
Complications and side effects
Critical Care
Diagnosis
Drug Overdose
Edema
Emergency medical care
Female
Humans
International Normalized Ratio
Liver failure
Liver Failure, Acute - chemically induced
Liver Failure, Acute - therapy
Liver transplantation
Mortality
Palliative Care
Pediatric acute-liver failure
Pediatrics
Poisoning
Recovery (Medical)
Risk factors
Tomography, X-Ray Computed
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Description
Summary:Acetaminophen is a common cause of acute liver failure in pediatrics. Cerebral edema is a significant complication of acute hepatic failure and is associated with increased mortality. We present a case of a 13 -year old girl with severe cerebral edema secondary to acetaminophen toxicity and hepatic failure. Her poor neurological status precluded her from liver transplantation and withdrawal of life sustaining treatment was recommended. However, with supportive care, she remarkably made a full recovery. This case highlights the difficulties surrounding prognostication in pediatric patients with cerebral edema from acute liver failure secondary to acetaminophen toxicity.
ISSN:1471-2431
1471-2431
DOI:10.1186/s12887-018-1233-5