Lactobacillus acidophilus and propionate attenuate Sjögren's syndrome by modulating the STIM1-STING signaling pathway

Sjögren's syndrome (SS) is an autoimmune disease characterized by inflammation of the exocrine gland. An imbalance of gut microbiota has been linked to SS. However, the molecular mechanism is unclear. We investigated the effects of Lactobacillus acidophilus (L. acidophilus) and propionate on th...

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Bibliographic Details
Published in:Cell communication and signaling 2023-06, Vol.21 (1), p.135-135, Article 135
Main Authors: Woo, Jin Seok, Hwang, Sun-Hee, Yang, SeungCheon, Lee, Kun Hee, Lee, Yeon Su, Choi, Jeong Won, Park, Jin-Sil, Jhun, JooYeon, Park, Sung-Hwan, Cho, Mi-La
Format: Article
Language:English
Subjects:
Animals
Antibodies
Autoimmune diseases
Exocrine glands
Gamma rays
Inflammation
Intestinal microflora
Laboratory animals
Lactobacillus acidophilus
Lupus
Mice
Microbiomes
Microbiota
Microscopy
Molecular modelling
Propionate
Propionates
Propionic acid
Saliva
Salivary gland
Signal Transduction
Sjogren's Syndrome
Sjögren’s syndrome
STIM1 protein
Stimulation of interferon genes (STING)
Stromal interaction moleculae 1 (STIM1)
Variance analysis
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Summary:Sjögren's syndrome (SS) is an autoimmune disease characterized by inflammation of the exocrine gland. An imbalance of gut microbiota has been linked to SS. However, the molecular mechanism is unclear. We investigated the effects of Lactobacillus acidophilus (L. acidophilus) and propionate on the development and progression of SS in mouse model. We compared the gut microbiomes of young and old mice. We administered L. acidophilus and propionate up to 24 weeks. The saliva flow rate and the histopathology of the salivary glands were investigated, and the effects of propionate on the STIM1-STING signaling pathway were evaluated in vitro. Lactobacillaceae and Lactobacillus were decreased in aged mice. SS symptoms were ameliorated by L. acidophilus. The abundance of propionate-producing bacterial was increased by L. acidophilus. Propionate ameliorated the development and progression of SS by inhibiting the STIM1-STING signaling pathway. The findings suggest that Lactobacillus acidophilus and propionate have therapeutic potential for SS. Video Abstract.
ISSN:1478-811X
1478-811X
DOI:10.1186/s12964-023-01141-0