Increased MDM2 expression is associated with inferior survival in mantle cell lymphoma, but not related to the MDM2 SNP309

* Institute of Pathology, University of Würzburg, Germany ° Hematopathology Section, Department of Pathology, Hospital Clinic, University of Barcelona, Spain Correspondence: Andreas Rosenwald, M.D., Institute of Pathology, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany. We h...

Full description

Saved in:
Bibliographic Details
Published in:Haematologica (Roma) 2007-04, Vol.92 (4), p.574-575
Main Authors: Hartmann, Elena, Fernandez, Veronica, Stoecklein, Heike, Hernandez, Luis, Campo, Elias, Rosenwald, Andreas
Format: Article
Language:English
Subjects:
Aged
DNA Damage
DNA Mutational Analysis
Female
Gene Dosage
Gene Duplication
Gene Expression Regulation, Neoplastic
Genes, p53
Humans
Lymphoma, Mantle-Cell - genetics
Lymphoma, Mantle-Cell - metabolism
Lymphoma, Mantle-Cell - mortality
Male
Middle Aged
Neoplasm Proteins - biosynthesis
Neoplasm Proteins - genetics
Neoplasm Proteins - physiology
Polymorphism, Single Nucleotide
Proportional Hazards Models
Proto-Oncogene Proteins c-mdm2 - biosynthesis
Proto-Oncogene Proteins c-mdm2 - genetics
Proto-Oncogene Proteins c-mdm2 - physiology
Reverse Transcriptase Polymerase Chain Reaction
Survival Analysis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:* Institute of Pathology, University of Würzburg, Germany ° Hematopathology Section, Department of Pathology, Hospital Clinic, University of Barcelona, Spain Correspondence: Andreas Rosenwald, M.D., Institute of Pathology, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany. We here show that increased expression of MDM2, a negative regulator of p53, correlates with inferior survival in a series of 43 mantle cell lymphomas. MDM2 overexpression is associated with copy number gains of the MDM2 locus in single tumors, but not with the recently reported MDM2 promoter SNP309. Key words: mantle cell lymphoma, MDM2 expression, survival, SNP309.
ISSN:0390-6078
1592-8721
DOI:10.3324/haematol.10891