Drug-induced hypersensitivity syndrome with rapid hematopoietic reconstitution during treatment for acute myeloid leukemia

• Published in: Haematologica (Roma) 2008-03, Vol.93 (3), p.469-470
• Main Authors: Suzuki, Hiroshi I, Asai, Takashi, Tamaki, Zenshiro, Hangaishi, Akira, Chiba, Shigeru, Kurokawa, Mineo
• Format: Article
• Language: English
• Subjects: Aged; Allopurinol - administration & dosage; Allopurinol - adverse effects; Allopurinol - therapeutic use; Anti-Infective Agents - administration & dosage; Anti-Infective Agents - adverse effects; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Bone Marrow - physiopathology; Cytarabine - administration & dosage; Cytarabine - adverse effects; Drug Eruptions - etiology; Exanthema Subitum - diagnosis; Exanthema Subitum - etiology; Exanthema Subitum - virology; Female; Fever - chemically induced; Hematopoiesis; Herpesvirus 6, Human - immunology; Herpesvirus 6, Human - physiology; Histiocytosis - etiology; Histiocytosis - pathology; Humans; Idarubicin - administration & dosage; Idarubicin - adverse effects; Immunocompromised Host; Leukemia, Myeloid, Acute - complications; Leukemia, Myeloid, Acute - drug therapy; Leukemia, Myeloid, Acute - pathology; Leukemia, Myelomonocytic, Acute - complications; Leukemia, Myelomonocytic, Acute - drug therapy; Leukemia, Myelomonocytic, Acute - pathology; Leukemic Infiltration - pathology; Middle Aged; Skin - pathology; Virus Activation - drug effects
• ISSN: 0390-6078; 1592-8721
• DOI: 10.3324/haematol.12029

1 Department of Hematology and Oncology 2 Department of Dermatology 3 Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan Key words: drug-induced hypersensitivity syndrome, immunorestitution disease, acute myeloid leukemia, chemotherapy, hematopoietic recovery Correspondence: Mineo Kurokawa, MD, PhD. Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan. Phone: international +81.3.5800-9092. Fax: international +81.3.58408667. E-mail: kurokawa-tky{at}umin.ac.jp Drug-induced hypersensitivity syndrome (DIHS) is a rare but severe life-threatening, drug-induced, systemic hypersensitivity reaction. We report two patients who developed DIHS during treatment for acute myeloid leukemia. Awareness of DIHS is necessary when systemic eruptions and high fever occur in leukemic patients, especially with rapid hematopoietic recovery after chemotherapies.