Modified wavelet analysis of ECoG-pattern as promising tool for detection of the blood–brain barrier leakage

A new approach for detection oscillatory patterns and estimation of their dynamics based by a modified CWT skeleton method is presented. The method opens up additional perspectives for the analysis of subtle changes in the oscillatory activity of complex nonstationary signals. The method was applied...

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Bibliographic Details
Published in:Scientific reports 2021-09, Vol.11 (1), p.18505-8, Article 18505
Main Authors: Runnova, Anastasiya, Zhuravlev, Maksim, Ukolov, Rodion, Blokhina, Inna, Dubrovski, Alexander, Lezhnev, Nikita, Sitnikova, Evgeniya, Saranceva, Elena, Kiselev, Anton, Karavaev, Anatoly, Selskii, Anton, Semyachkina-Glushkovskaya, Oxana, Penzel, Thomas, Kurths, Jurgen
Format: Article
Language:English
Subjects:
631/378/116
631/378/1341
631/57/2266
Animals
Blood-brain barrier
Blood-Brain Barrier - physiology
Brain - physiology
Electrocorticography
Humanities and Social Sciences
Male
Membrane permeability
multidisciplinary
Permeability
Rats
Rats, Wistar
Science
Science (multidisciplinary)
Sleep
Sleep - physiology
Sleep and wakefulness
Wakefulness - physiology
Wavelet Analysis
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Summary:A new approach for detection oscillatory patterns and estimation of their dynamics based by a modified CWT skeleton method is presented. The method opens up additional perspectives for the analysis of subtle changes in the oscillatory activity of complex nonstationary signals. The method was applied to analyze unique experimental signals obtained in usual conditions and after the non-invasive increase in the blood–brain barrier (BBB) permeability in 10 male Wistar rats. The results of the wavelet-analysis of electrocorticography (ECoG) recorded in a normal physiological state and after an increase in the BBB permeability of animals demonstrate significant changes between these states during wakefulness of animals and an essential smoothing of these differences during sleep. Sleep is closely related to the processes of observed changes in the BBB permeability.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-97427-9