Hollow porous PLA/PBAT composite microfibers with enhanced toughness and prolonged drug release for wound healing

An appropriate wound dressing is necessary to enhance the recovery of wounds and the restoration of tissue after the skin gets injured. In this study, a hollow porous microfiber (HPMF) scaffold composed of a combination of polylactic acid (PLA)/polybutylene adipate/butylene terephthalate (PBAT)/poly...

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Bibliographic Details
Published in:Materials & design 2024-01, Vol.237, p.112624, Article 112624
Main Authors: Liu, Yufei, Wei, Yuanzhi, Xiong, Qinqin, Xie, Chuan, An, Taofang, He, Min, Xia, Lu, Wei, Shinan, Yu, Jia, Cheng, Sha, Xu, Bixue, Ahmad, Mashaal, Zeng, Xi, Yu, Jie, Luo, Sihai, Luo, Heng
Format: Article
Language:English
Subjects:
Electrospinning
Microfiber
Polylactic acid
Tissue engineering
Wound healing
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Summary:An appropriate wound dressing is necessary to enhance the recovery of wounds and the restoration of tissue after the skin gets injured. In this study, a hollow porous microfiber (HPMF) scaffold composed of a combination of polylactic acid (PLA)/polybutylene adipate/butylene terephthalate (PBAT)/polyvinyl alcohol (PVA) was developed using coaxial electrospinning for wound healing. The porous structure of PLA/PBAT HPMFs was formed by dissolving PVA in water. The results showed that when maintaining a PLA: PBAT weight ratio of 7:3, high-quality porous PLA/PBAT composites were achieved, leading to a 36.25% increase in toughness and a 4.9% increase in biodegradability compared to pure PLA. Furthermore, in vivo wound healing assays suggest that composites successfully loaded can effectively promote wound healing on the 13th day. Therefore, this work underscores the significant potential of PLA/PBAT HPMF dressing for wound repair.
ISSN:0264-1275
DOI:10.1016/j.matdes.2023.112624