Natural Antioxidant Application on Fat Accumulation: Preclinical Evidence

Obesity represents one of the most important challenges in the contemporary world that must be overcome. Different pathological consequences of these physical conditions have been studied for more than 30 years. The most nagging effects were found early in the cardiovascular system. However, later,...

Full description

Saved in:
Bibliographic Details
Published in:Antioxidants 2021-05, Vol.10 (6), p.858
Main Authors: Roy, Proshanta, Tomassoni, Daniele, Traini, Enea, Martinelli, Ilenia, Micioni Di Bonaventura, Maria Vittoria, Cifani, Carlo, Amenta, Francesco, Tayebati, Seyed Khosrow
Format: Article
Language:English
Subjects:
Animal models
antioxidant
Antioxidants
Bioavailability
Biological activity
Cardiovascular system
Disease
DNA methylation
Flavonoids
Food
Free radicals
Fruits
Glucose
Health care
Inflammation
Metabolism
Metabolites
Microbiota
Obesity
Oxidants
Oxidative stress
Polyphenols
preclinical studies
Preventive medicine
Reactive oxygen species
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Obesity represents one of the most important challenges in the contemporary world that must be overcome. Different pathological consequences of these physical conditions have been studied for more than 30 years. The most nagging effects were found early in the cardiovascular system. However, later, its negative impact was also investigated in several other organs. Damage at cellular structures due to overexpression of reactive oxygen species together with mechanisms that cause under-production of antioxidants leads to the development of obesity-related complications. In this view, the negative results of oxidant molecules due to obesity were studied in various districts of the body. In the last ten years, scientific literature has reported reasonable evidence regarding natural and synthetic compounds’ supplementation, which showed benefits in reducing oxidative stress and inflammatory processes in animal models of obesity. This article attempts to clarify the role of oxidative stress due to obesity and the opposing role of antioxidants to counter it, reported in preclinical studies. This analysis aims to clear-up different mechanisms that lead to the build-up of pro-oxidants during obesity and how various molecules of different origins hinder this phenomenon, behaving as antioxidants.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox10060858