Hirudin versus citrate as an anticoagulant for ROTEM platelet whole blood impedance aggregometry in thrombocytopenic patients

Citrate is widely used as an anticoagulant for platelet function tests (PFTs). Due to an intrinsic inhibitory effect of citrate on platelet function, hirudin is used as an alternative. However, studies comparing the effect of these anticoagulants on rotational thromboelastometry (ROTEM) platelet who...

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Bibliographic Details
Published in:Platelets (Edinburgh) 2023-12, Vol.34 (1), p.2229909-2229909
Main Authors: Wickramasinghe, Wasanthi, Alvitigala, Bhawani Yasassri, Perera, Thisarika, Karunanayake, Panduka, Jayasinghe, Saroj, Rajapakse, Senaka, Weeratunga, Praveen, Wijewickrama, Ananda, Arya, Roopen, Goerlinger, Klaus, Gooneratne, Lallindra Viranjan
Format: Article
Language:English
Subjects:
Anticoagulants - pharmacology
Anticoagulants - therapeutic use
Blood Platelets
citrate
Citrates - pharmacology
Citric Acid - pharmacology
Citric Acid - therapeutic use
Cross-Sectional Studies
Electric Impedance
hirudin
Hirudins - pharmacology
Humans
Platelet Aggregation
Thrombelastography
thrombocytopenia
Thrombocytopenia - drug therapy
whole blood impedance aggregometry
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Summary:Citrate is widely used as an anticoagulant for platelet function tests (PFTs). Due to an intrinsic inhibitory effect of citrate on platelet function, hirudin is used as an alternative. However, studies comparing the effect of these anticoagulants on rotational thromboelastometry (ROTEM) platelet whole blood impedance aggregometry in thrombocytopenic patients are scant. Cross-sectional study was done in 105 patients who entered the critical phase of Dengue hemorrhagic fever with plasma leakage and severe thrombocytopenia (
ISSN:0953-7104
1369-1635
DOI:10.1080/09537104.2023.2229909