The IL-17 family in diseases: from bench to bedside

The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and recently, all of its related receptors have been discovered. IL-17 was first discovered approximately 30 years ago. Members of this family have various biological functions, including driving an inflammatory cascade during inf...

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Bibliographic Details
Published in:Signal transduction and targeted therapy 2023-10, Vol.8 (1), p.402-402, Article 402
Main Authors: Huangfu, Longjie, Li, Ruiying, Huang, Yamei, Wang, Shan
Format: Article
Language:English
Subjects:
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Autoimmune diseases
Autoimmune Diseases - genetics
Cancer Research
Cell Biology
Cytokines
Humans
Inflammation
Inflammatory diseases
Interleukin 17
Interleukin-17 - genetics
Internal Medicine
Medicine
Medicine & Public Health
Metastases
Oncology
Pathogenesis
Pathology
Review
Review Article
Reviews
Signal transduction
Signal Transduction - genetics
Systemic lupus erythematosus
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Summary:The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and recently, all of its related receptors have been discovered. IL-17 was first discovered approximately 30 years ago. Members of this family have various biological functions, including driving an inflammatory cascade during infections and autoimmune diseases, as well as boosting protective immunity against various pathogens. IL-17 is a highly versatile proinflammatory cytokine necessary for vital processes including host immune defenses, tissue repair, inflammatory disease pathogenesis, and cancer progression. However, how IL-17 performs these functions remains controversial. The multifunctional properties of IL-17 have attracted research interest, and emerging data have gradually improved our understanding of the IL-17 signaling pathway. However, a comprehensive review is required to understand its role in both host defense functions and pathogenesis in the body. This review can aid researchers in better understanding the mechanisms underlying IL-17’s roles in vivo and provide a theoretical basis for future studies aiming to regulate IL-17 expression and function. This review discusses recent progress in understanding the IL-17 signaling pathway and its physiological roles. In addition, we present the mechanism underlying IL-17’s role in various pathologies, particularly, in IL-17-induced systemic lupus erythematosus and IL-17-related tumor cell transformation and metastasis. In addition, we have briefly discussed promising developments in the diagnosis and treatment of autoimmune diseases and tumors.
ISSN:2059-3635
2095-9907
2059-3635
DOI:10.1038/s41392-023-01620-3