Functionalization of Fe3O4 nanoparticles with biodegradable chitosan-grafted-mPEG for paclitaxel delivery

• Published in: Green processing and synthesis 2016-10, Vol.5 (5), p.459-466
• Main Authors: Hoang, Dong Quy, Tran, Tuong Vi, Tran, Ngoc Quyen, Nguyen, Cuu Khoa, Nguyen, Thi Hiep, Truong, Minh Dung, Tran, Dai Lam, Thu, Le Van, Nguyen, Dai Hai
• Format: Article
• Language: English
• Subjects: Biodegradation; chitosan; controlled drug delivery; Fourier transforms; Iron oxides; NMR; Nuclear magnetic resonance; paclitaxel; poly(ethylene glycol); superparamagnetic iron oxide; X-ray diffraction
• ISSN: 2191-9542; 2191-9550
• DOI: 10.1515/gps-2016-0093

In this report, magnetic Fe nanoparticles were functionalized with chitosan-grafted-poly(ethylene glycol) methyl ether (CTS-mPEG) for paclitaxel (PTX) delivery. The Fe nanoparticles were prepared via the chemical coprecipitation method and then coated with CTS-mPEG (Fe @CTS-mPEG) by a simple method. The formation of Fe @CTS-mPEG was characterized by several methods including proton nuclear magnetic resonance spectroscopy, Fourier transform infrared, and X-ray diffraction. Furthermore, the superparamagnetic properties of Fe @CTS-mPEG were demonstrated by a vibrating sample magnetometer; the saturation magnetization reached 23 emu g . The sizes and morphologies of Fe and Fe @CTS-mPEG nanoparticles were determined by transmission electron microscopy. The result indicated that Fe @CTS-mPEGs were nearly spherical in shape with an average diameter of 20 nm, compared with the 12-nm Fe particles. Especially, PTX was effectively loaded into the coated nanoparticles, 86.9±3.4% for drug loading efficiency, and slowly released up to 120 h. These results suggest the potential applications of Fe @CTS-mPEG in the development of stable drug delivery systems for cancer treatment.