The efficacy of therapies for post-stroke depression in aging: An umbrella review

Post-stroke depression (PSD) is a common complication after stroke. PSD is associated with emotional disorders and psychological dependence, which are potential risk factors for stroke recurrence and suicidality. This study aimed to perform an umbrella review of therapies for PSD through a comprehen...

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Published in:Frontiers in aging neuroscience 2022-08, Vol.14, p.993250-993250
Main Authors: Xie, Jinlu, Geng, Xiwen, Fan, Fangcheng, Fu, Xuyan, He, Shuaibing, Li, Tao
Format: Article
Language:English
Subjects:
Activities of daily living
Acupuncture
Adverse events
Aging
Aging Neuroscience
Citalopram
Clinical trials
Cognitive ability
Fluoxetine
Herbal medicine
Magnetic fields
Mental depression
Meta-analysis
Mortality
Paroxetine
Patients
post-stroke depression
Psychotherapy
Risk factors
Sertraline
Stroke
systematic review
therapies
Transcranial magnetic stimulation
umbrella review
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Summary:Post-stroke depression (PSD) is a common complication after stroke. PSD is associated with emotional disorders and psychological dependence, which are potential risk factors for stroke recurrence and suicidality. This study aimed to perform an umbrella review of therapies for PSD through a comprehensive literature search. A systematic search was conducted in the PubMed and Web of Science by two independent authors. We examined the Hamilton Depression Scale (HAMD), Activities of daily living (ADL), Neurologic function as efficacy endpoints, and the incidence of adverse events as safety profiles. Seventeen eligible studies, including 267 clinical trials were included in this study. The results showed that High-Frequency Repetitive Transcranial Magnetic Stimulation (HfrTMS), Acupuncture/EA+conventional treatment, Escitalopram, Modified Sini San, Moxibustion, Xiaoyao Formula, Paroxetine, Chinese herbal medicine, Exercise, Citalopram, and Cognitive behavioral therapy are beneficial for improving the depression symptoms of patients with PSD. HfrTMS and Sertraline may have an impact on slowing the scores of activities of daily living or neurologic function. In addition, Acupuncture/EA+conventional, Escitalopram, Citalopram, Sertraline, and Fluoxetine showed no serious adverse events in PSD patients. Our study demonstrated that 11 treatment methods can effectively improve the condition of PSD patients.
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2022.993250