Effects of Methamphetamine on Single Unit Activity in Rat Medial Prefrontal Cortex In Vivo

To investigate how neuronal activity in the prefrontal cortex changes in an animal model of schizophrenia, we recorded single unit activity in the medial prefrontal cortex of urethane-anesthetized and awake rats following methamphetamine (MA) administration. Systemic MA injection (4 mg/kg, IP) induc...

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Bibliographic Details
Published in:Journal of Neural Transplantation & Plasticity 2007, Vol.2007, p.170-178
Main Authors: Jang, Jinhwa, Ha, Hee-Jin, Kim, Yun Bok, Chung, Young-Ki, Jung, Min Whan
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Action Potentials - physiology
Animals
Causes of
Development and progression
Disease Models, Animal
Dopamine - metabolism
Dopamine Uptake Inhibitors - pharmacology
Evaluation
Health aspects
Male
Methamphetamine
Methamphetamine - pharmacology
Neural circuitry
Neurons - drug effects
Neurons - physiology
Physiological aspects
Prefrontal cortex
Prefrontal Cortex - anatomy & histology
Prefrontal Cortex - drug effects
Prefrontal Cortex - physiology
Properties
Psychoses, Substance-Induced - metabolism
Psychoses, Substance-Induced - physiopathology
Rats
Rats, Sprague-Dawley
Schizophrenia
Schizophrenia - chemically induced
Schizophrenia - metabolism
Schizophrenia - physiopathology
Stochastic Processes
Synaptic Transmission - drug effects
Synaptic Transmission - physiology
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Description
Summary:To investigate how neuronal activity in the prefrontal cortex changes in an animal model of schizophrenia, we recorded single unit activity in the medial prefrontal cortex of urethane-anesthetized and awake rats following methamphetamine (MA) administration. Systemic MA injection (4 mg/kg, IP) induced inconsistent changes, that is, both enhancement and reduction, in unit discharge rate, with a subset of neurons transiently (
ISSN:0792-8483
2090-5904
1687-5443
DOI:10.1155/2007/29821