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Effects of Methamphetamine on Single Unit Activity in Rat Medial Prefrontal Cortex In Vivo
To investigate how neuronal activity in the prefrontal cortex changes in an animal model of schizophrenia, we recorded single unit activity in the medial prefrontal cortex of urethane-anesthetized and awake rats following methamphetamine (MA) administration. Systemic MA injection (4 mg/kg, IP) induc...
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| Published in: | Journal of Neural Transplantation & Plasticity 2007, Vol.2007, p.170-178 |
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| cites | cdi_FETCH-LOGICAL-a5471-e121f24161abce8c3ef47bc141d594d4b99d87233704da02284c4e6f302292b23 |
| container_end_page | 178 |
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| container_start_page | 170 |
| container_title | Journal of Neural Transplantation & Plasticity |
| container_volume | 2007 |
| creator | Jang, Jinhwa Ha, Hee-Jin Kim, Yun Bok Chung, Young-Ki Jung, Min Whan |
| description | To investigate how neuronal activity in the prefrontal cortex changes in an animal model of schizophrenia, we recorded single unit activity in the medial prefrontal cortex of urethane-anesthetized and awake rats following methamphetamine (MA) administration. Systemic MA injection (4 mg/kg, IP) induced inconsistent changes, that is, both enhancement and reduction, in unit discharge rate, with a subset of neurons transiently ( |
| doi_str_mv | 10.1155/2007/29821 |
| format | article |
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Systemic MA injection (4 mg/kg, IP) induced inconsistent changes, that is, both enhancement and reduction, in unit discharge rate, with a subset of neurons transiently (<30 min) elevating their activities. The direction of firing rate change was poorly predicted by the mean firing rate or the degree of burst firing during the baseline period. Also, simultaneously recorded units showed opposite directions of firing rate change, indicating that recording location is a poor predictor of the direction of firing rate change. These results raise the possibility that systemic MA injection induces random bidirectional changes in prefrontal cortical unit activity, which may underlie some of MA-induced psychotic symptoms.</description><identifier>ISSN: 0792-8483</identifier><identifier>ISSN: 2090-5904</identifier><identifier>EISSN: 1687-5443</identifier><identifier>DOI: 10.1155/2007/29821</identifier><identifier>PMID: 18288241</identifier><language>eng</language><publisher>United States: Hindawi Limiteds</publisher><subject>Action Potentials - drug effects ; Action Potentials - physiology ; Animals ; Causes of ; Development and progression ; Disease Models, Animal ; Dopamine - metabolism ; Dopamine Uptake Inhibitors - pharmacology ; Evaluation ; Health aspects ; Male ; Methamphetamine ; Methamphetamine - pharmacology ; Neural circuitry ; Neurons - drug effects ; Neurons - physiology ; Physiological aspects ; Prefrontal cortex ; Prefrontal Cortex - anatomy & histology ; Prefrontal Cortex - drug effects ; Prefrontal Cortex - physiology ; Properties ; Psychoses, Substance-Induced - metabolism ; Psychoses, Substance-Induced - physiopathology ; Rats ; Rats, Sprague-Dawley ; Schizophrenia ; Schizophrenia - chemically induced ; Schizophrenia - metabolism ; Schizophrenia - physiopathology ; Stochastic Processes ; Synaptic Transmission - drug effects ; Synaptic Transmission - physiology</subject><ispartof>Journal of Neural Transplantation & Plasticity, 2007, Vol.2007, p.170-178</ispartof><rights>COPYRIGHT 2007 John Wiley & Sons, Inc.</rights><rights>Copyright © 2007 Jinhwa Jang et al. 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a5471-e121f24161abce8c3ef47bc141d594d4b99d87233704da02284c4e6f302292b23</citedby><cites>FETCH-LOGICAL-a5471-e121f24161abce8c3ef47bc141d594d4b99d87233704da02284c4e6f302292b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2220029/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2220029/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18288241$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jang, Jinhwa</creatorcontrib><creatorcontrib>Ha, Hee-Jin</creatorcontrib><creatorcontrib>Kim, Yun Bok</creatorcontrib><creatorcontrib>Chung, Young-Ki</creatorcontrib><creatorcontrib>Jung, Min Whan</creatorcontrib><title>Effects of Methamphetamine on Single Unit Activity in Rat Medial Prefrontal Cortex In Vivo</title><title>Journal of Neural Transplantation & Plasticity</title><addtitle>Neural Plast</addtitle><description>To investigate how neuronal activity in the prefrontal cortex changes in an animal model of schizophrenia, we recorded single unit activity in the medial prefrontal cortex of urethane-anesthetized and awake rats following methamphetamine (MA) administration. Systemic MA injection (4 mg/kg, IP) induced inconsistent changes, that is, both enhancement and reduction, in unit discharge rate, with a subset of neurons transiently (<30 min) elevating their activities. The direction of firing rate change was poorly predicted by the mean firing rate or the degree of burst firing during the baseline period. Also, simultaneously recorded units showed opposite directions of firing rate change, indicating that recording location is a poor predictor of the direction of firing rate change. These results raise the possibility that systemic MA injection induces random bidirectional changes in prefrontal cortical unit activity, which may underlie some of MA-induced psychotic symptoms.</description><subject>Action Potentials - drug effects</subject><subject>Action Potentials - physiology</subject><subject>Animals</subject><subject>Causes of</subject><subject>Development and progression</subject><subject>Disease Models, Animal</subject><subject>Dopamine - metabolism</subject><subject>Dopamine Uptake Inhibitors - pharmacology</subject><subject>Evaluation</subject><subject>Health aspects</subject><subject>Male</subject><subject>Methamphetamine</subject><subject>Methamphetamine - pharmacology</subject><subject>Neural circuitry</subject><subject>Neurons - drug effects</subject><subject>Neurons - physiology</subject><subject>Physiological aspects</subject><subject>Prefrontal cortex</subject><subject>Prefrontal Cortex - anatomy & histology</subject><subject>Prefrontal Cortex - drug effects</subject><subject>Prefrontal Cortex - physiology</subject><subject>Properties</subject><subject>Psychoses, Substance-Induced - metabolism</subject><subject>Psychoses, Substance-Induced - physiopathology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Schizophrenia</subject><subject>Schizophrenia - chemically induced</subject><subject>Schizophrenia - metabolism</subject><subject>Schizophrenia - physiopathology</subject><subject>Stochastic Processes</subject><subject>Synaptic Transmission - drug effects</subject><subject>Synaptic Transmission - physiology</subject><issn>0792-8483</issn><issn>2090-5904</issn><issn>1687-5443</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqFkk2LUzEUhi-iOJ3RjT9ALgguBurk5PtuhFJGLVQc1HHhJuTm5rYpt0lN0uL8e9MPHLtyEc7JycObnLynql4BegfA2A1GSNzgRmJ4Uo2ASzFmlJKn1QiJBo8lleSiukxphRBjgNnz6gIklhJTGFU_b_vempzq0NefbV7q9WZps147b-vg62_OLwZb33uX64nJbufyQ-18_VXngndOD_VdtH0MPpd0GmK2v-uZr3-4XXhRPev1kOzLU7yq7j_cfp9-Gs-_fJxNJ_OxZlTA2AKGvryFg26NlYbYnorWAIWONbSjbdN0UmBCBKKdRhhLaqjlPSlpg1tMrqrZUbcLeqU20a11fFBBO3UohLhQOmZnBqt6q6mRvBEMIcr6tuWo7XgnDLfMWEBF6_1Ra7Nt17Yz1ueohzPR8xPvlmoRdgrj4gJuisDbk0AMv7Y2ZbV2ydhh0N6GbVKEEU73lvwPhAZL0mBewDdHcKFLB873oVxs9rCagJBIyIbTR7kDtbR6yMsUhm12wadz8PoImhhSKt79bQ6Q2o-T2o-TOoxTgV__-x2P6Gl-CjA_AtpFl51ahW30xWx1hxFwxAhCCA6KgEsAgTDIUkLnm5KWJckfNdjWUQ</recordid><startdate>2007</startdate><enddate>2007</enddate><creator>Jang, Jinhwa</creator><creator>Ha, Hee-Jin</creator><creator>Kim, Yun Bok</creator><creator>Chung, Young-Ki</creator><creator>Jung, Min Whan</creator><general>Hindawi Limiteds</general><general>John Wiley & Sons, Inc</general><general>Hindawi Publishing Corporation</general><general>Hindawi Limited</general><scope>188</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U5</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>L7M</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>2007</creationdate><title>Effects of Methamphetamine on Single Unit Activity in Rat Medial Prefrontal Cortex In Vivo</title><author>Jang, Jinhwa ; Ha, Hee-Jin ; Kim, Yun Bok ; Chung, Young-Ki ; Jung, Min Whan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a5471-e121f24161abce8c3ef47bc141d594d4b99d87233704da02284c4e6f302292b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Action Potentials - drug effects</topic><topic>Action Potentials - physiology</topic><topic>Animals</topic><topic>Causes of</topic><topic>Development and progression</topic><topic>Disease Models, Animal</topic><topic>Dopamine - metabolism</topic><topic>Dopamine Uptake Inhibitors - pharmacology</topic><topic>Evaluation</topic><topic>Health aspects</topic><topic>Male</topic><topic>Methamphetamine</topic><topic>Methamphetamine - pharmacology</topic><topic>Neural circuitry</topic><topic>Neurons - drug effects</topic><topic>Neurons - physiology</topic><topic>Physiological aspects</topic><topic>Prefrontal cortex</topic><topic>Prefrontal Cortex - anatomy & histology</topic><topic>Prefrontal Cortex - drug effects</topic><topic>Prefrontal Cortex - physiology</topic><topic>Properties</topic><topic>Psychoses, Substance-Induced - metabolism</topic><topic>Psychoses, Substance-Induced - physiopathology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Schizophrenia</topic><topic>Schizophrenia - chemically induced</topic><topic>Schizophrenia - metabolism</topic><topic>Schizophrenia - physiopathology</topic><topic>Stochastic Processes</topic><topic>Synaptic Transmission - drug effects</topic><topic>Synaptic Transmission - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jang, Jinhwa</creatorcontrib><creatorcontrib>Ha, Hee-Jin</creatorcontrib><creatorcontrib>Kim, Yun Bok</creatorcontrib><creatorcontrib>Chung, Young-Ki</creatorcontrib><creatorcontrib>Jung, Min Whan</creatorcontrib><collection>Airiti Library</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Journal of Neural Transplantation & Plasticity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jang, Jinhwa</au><au>Ha, Hee-Jin</au><au>Kim, Yun Bok</au><au>Chung, Young-Ki</au><au>Jung, Min Whan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Methamphetamine on Single Unit Activity in Rat Medial Prefrontal Cortex In Vivo</atitle><jtitle>Journal of Neural Transplantation & Plasticity</jtitle><addtitle>Neural Plast</addtitle><date>2007</date><risdate>2007</risdate><volume>2007</volume><spage>170</spage><epage>178</epage><pages>170-178</pages><issn>0792-8483</issn><issn>2090-5904</issn><eissn>1687-5443</eissn><abstract>To investigate how neuronal activity in the prefrontal cortex changes in an animal model of schizophrenia, we recorded single unit activity in the medial prefrontal cortex of urethane-anesthetized and awake rats following methamphetamine (MA) administration. 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| fulltext | fulltext |
| identifier | ISSN: 0792-8483 |
| ispartof | Journal of Neural Transplantation & Plasticity, 2007, Vol.2007, p.170-178 |
| issn | 0792-8483 2090-5904 1687-5443 |
| language | eng |
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| source | NCBI_PubMed Central（免费）; Wiley Online Library Open Access |
| subjects | Action Potentials - drug effects Action Potentials - physiology Animals Causes of Development and progression Disease Models, Animal Dopamine - metabolism Dopamine Uptake Inhibitors - pharmacology Evaluation Health aspects Male Methamphetamine Methamphetamine - pharmacology Neural circuitry Neurons - drug effects Neurons - physiology Physiological aspects Prefrontal cortex Prefrontal Cortex - anatomy & histology Prefrontal Cortex - drug effects Prefrontal Cortex - physiology Properties Psychoses, Substance-Induced - metabolism Psychoses, Substance-Induced - physiopathology Rats Rats, Sprague-Dawley Schizophrenia Schizophrenia - chemically induced Schizophrenia - metabolism Schizophrenia - physiopathology Stochastic Processes Synaptic Transmission - drug effects Synaptic Transmission - physiology |
| title | Effects of Methamphetamine on Single Unit Activity in Rat Medial Prefrontal Cortex In Vivo |
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