New Thio-Compounds and Monoterpenes With Anti-inflammatory Activities From the Fungus Aspergillus sp. CYH26

Two new thio-compounds named aspergerthinol A and B ( and ) and two new monoterpenes named aspergerthinacids A and B ( and ) were isolated from the fungus sp. CYH26 from the rhizosphere soil of Decne. The structures of compounds were elucidated by spectroscopic data and quantum NMR and ECD calculati...

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Published in:Frontiers in microbiology 2021-03, Vol.12, p.668938-668938
Main Authors: Pan, Guojun, Li, Yanling, Che, Xinyu, Tian, Dan, Han, Wenjie, Wang, Zimin, Zhao, Yanfen, Ren, Shuang, Xu, Yiru, Hao, Gangping, Guo, Mengfei, Xiao, Na, Kong, Fandong
Format: Article
Language:English
Subjects:
anti-inflammatory activity
Aspergillus sp. CYH26
fungus
Microbiology
monoterpenes
thio-compounds
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Summary:Two new thio-compounds named aspergerthinol A and B ( and ) and two new monoterpenes named aspergerthinacids A and B ( and ) were isolated from the fungus sp. CYH26 from the rhizosphere soil of Decne. The structures of compounds were elucidated by spectroscopic data and quantum NMR and ECD calculations. Compounds and represented a new family of sulfur containing natural products with a 3-methyl-4 -cyclopenta[b]thiophen-4-one skeleton. Compounds showed inhibitory activities against nitric oxide (NO) with IC values of 38.0, 19.8, 46.3, and 56.6 μM, respectively.
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2021.668938